Ethyl 3-(5-amino-2,4-dioxo-3,4-dihydropyrimidin-1(2h)-yl)propanoate

Base Information

Chemical Name:Ethyl 3-(5-amino-2,4-dioxo-3,4-dihydropyrimidin-1(2h)-yl)propanoate
CAS No.:2950-92-7
Molecular Formula:C₉H₁₃N₃O₄
Molecular Weight:227.22
Hs Code.:
NSC Number:73277
DSSTox Substance ID:DTXSID50291123
Wikidata:Q82028973

Synonyms:2950-92-7;ethyl 3-(5-amino-2,4-dioxo-3,4-dihydropyrimidin-1(2h)-yl)propanoate;NSC73277;DTXSID50291123;NSC-73277

Suppliers and Price of Ethyl 3-(5-amino-2,4-dioxo-3,4-dihydropyrimidin-1(2h)-yl)propanoate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 5 raw suppliers

Chemical Property of Ethyl 3-(5-amino-2,4-dioxo-3,4-dihydropyrimidin-1(2h)-yl)propanoate

Chemical Property:

Density:1.291g/cm³
XLogP3:-1.1
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:5
Exact Mass:227.09060590
Heavy Atom Count:16
Complexity:351

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CCOC(=O)CCN1C=C(C(=O)NC1=O)N

Technology Process of Ethyl 3-(5-amino-2,4-dioxo-3,4-dihydropyrimidin-1(2h)-yl)propanoate

There total 3 articles about Ethyl 3-(5-amino-2,4-dioxo-3,4-dihydropyrimidin-1(2h)-yl)propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 2950-88-1
3-(5-nitro-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)propionic acid ethyl ester

: 2950-92-7
ethyl 3-[5-amino-2,4-(1H,3H)pyrimidinedione]propanoate

Guidance literature:: With hydrogen; 10percent Pd/C; In 2-methoxy-ethanol; at 20 ℃; for 2h; under 2844.39 Torr;
DOI:10.1021/jm011113b

Reference yield:

: 539-74-2
Ethyl 3-bromopropionate

: 2950-92-7
ethyl 3-[5-amino-2,4-(1H,3H)pyrimidinedione]propanoate

Guidance literature:: Multi-step reaction with 2 steps

1.1: NaH / dimethylformamide / 1 h / 100 °C

1.2: 18 percent / dimethylformamide / 24 h / 20 °C

2.1: 92 percent / H₂ / 10percent Pd/C / 2-methoxy-ethanol / 2 h / 20 °C / 2844.39 Torr

With hydrogen; sodium hydride; 10percent Pd/C; In 2-methoxy-ethanol; N,N-dimethyl-formamide;
DOI:10.1021/jm011113b

Reference yield:

: 2950-92-7
ethyl 3-[5-amino-2,4-(1H,3H)pyrimidinedione]propanoate

Guidance literature:: 3-<3,4-Dihydro-2,4-dioxo-5-nitro-1(2H)-pyrimidin>-propionsaeure-aethylester, H2, Pd, 2-Methoxy-aethanol;
DOI:10.1021/jm00326a009