4-(1-Azepanylsulfonyl)aniline

Base Information

• Chemical Name: 4-(1-Azepanylsulfonyl)aniline
• CAS No.: 109286-01-3
• Molecular Formula: C12H18 N2 O2 S
• Molecular Weight: 254.353
• Hs Code.: 2933990090
• Mol file: 109286-01-3.mol

Synonyms:1H-Azepine,1-[(4-aminophenyl)sulfonyl]hexahydro- (9CI); Hexamethylenimine, 1-sulfanilyl-(6CI); 4-((Azepan-1-yl)sulfonyl)aniline

Chemical Property of 4-(1-Azepanylsulfonyl)aniline

Chemical Property:

• Vapor Pressure: 1.21E-07mmHg at 25°C
• Boiling Point: 431.3°Cat760mmHg
• Flash Point: 214.7°C
• PSA: 71.78000
• Density: 1.241g/cm³
• LogP: 3.43340

Purity/Quality:

98%min ^*data from raw suppliers

4-(Azepan-1-ylsulfonyl)aniline ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-(1-Azepanylsulfonyl)aniline

There total 4 articles about 4-(1-Azepanylsulfonyl)aniline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N,N-Hexamethylen-4-nitrobenzol-sulfonamid (153439-47-5) → 1-sulfanilyl-hexahydro-azepine (109286-01-3)

Guidance literature:

With ammonium formate; palladium 10% on activated carbon; In methanol; ethyl acetate; at 25 ℃;

Reference yield:

1-(N-acetyl-sulfanilyl)-hexahydro-azepine (109473-93-0) → 1-sulfanilyl-hexahydro-azepine (109286-01-3)

Guidance literature:

With hydrogenchloride;

Reference yield:

hexamethylene imine (111-49-9) → 1-sulfanilyl-hexahydro-azepine (109286-01-3)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium carbonate; water

2: aqueous hydrochloric acid

With hydrogenchloride; water; sodium carbonate;

upstream raw materials:

1-(N-acetyl-sulfanilyl)-hexahydro-azepine

hexamethylene imine

p-acetylaminobenzenesulfonyl chloride

N,N-Hexamethylen-4-nitrobenzol-sulfonamid

Downstream raw materials:

C₁₈H₂₁F₃N₄O₃S

Refernces

• 1、 Sun, Aiming,Yoon, Jeong-Joong,Yin, Yan,Prussia, Andrew,Yang, Yutao,Min, Jaeki,Plemper, Richard K.,Snyder, James P.. "Potent non-nucleoside inhibitors of the measles virus RNA-dependent RNA polymerase complex". experimental part. p. 3731 - 3741. Retrieved 2009/04/10.