Dimethyl (2-oxo-3-phenylbutyl)phosphonate

Base Information

Chemical Name:Dimethyl (2-oxo-3-phenylbutyl)phosphonate
CAS No.:57973-25-8
Molecular Formula:C₁₂H₁₇O₄P
Molecular Weight:256.238
Hs Code.:
DSSTox Substance ID:DTXSID70537676

Synonyms:57973-25-8;Dimethyl (2-oxo-3-phenylbutyl)phosphonate;SCHEMBL9215162;DTXSID70537676

Suppliers and Price of Dimethyl (2-oxo-3-phenylbutyl)phosphonate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Dimethyl (2-oxo-3-phenylbutyl)phosphonate

Chemical Property:

PSA：62.41000
LogP:2.84510
XLogP3:1.4
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:6
Exact Mass:256.08644602
Heavy Atom Count:17
Complexity:289

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC(C1=CC=CC=C1)C(=O)CP(=O)(OC)OC

Technology Process of Dimethyl (2-oxo-3-phenylbutyl)phosphonate

There total 1 articles about Dimethyl (2-oxo-3-phenylbutyl)phosphonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 756-79-6
dimethyl methane phosphonate

: 101-41-7
benzeneacetic acid methyl ester

: 52343-38-1
dimethyl 2-oxo-3-phenylpropylphosphonate

: 57973-25-8
(2-Oxo-3-phenyl-butyl)-phosphonic acid dimethyl ester

Guidance literature:: dimethyl methane phosphonate; With n-butyllithium;

benzeneacetic acid methyl ester;
DOI:10.1016/j.bmcl.2004.01.063

Reference yield:

: 57973-25-8
(2-Oxo-3-phenyl-butyl)-phosphonic acid dimethyl ester

: 126451-82-9
<1R-<1α,2α(Z),3α(1E,3S^*,4S^*),4α>>-7-<3-(3-hydroxy-4-phenyl-1-pentenyl)-7-oxabicyclo<2.2.1>hept-2-yl>-5-heptenoic acid

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) LiBr, Et₃N / 1.) CH₂Cl₂, RT, 40 min 2.) RT, overnight

2: CeCl₃*7H₂O, NaBH₄ / tetrahydrofuran; methanol / 2.25 h / -50 - -30 °C

3: aq. LiOH / tetrahydrofuran / 4.5 h / Ambient temperature

With lithium hydroxide; sodium tetrahydroborate; cerium(III) chloride; triethylamine; lithium bromide; In tetrahydrofuran; methanol;
DOI:10.1021/jm00168a032

Reference yield:

: 57973-25-8
(2-Oxo-3-phenyl-butyl)-phosphonic acid dimethyl ester

: 87929-82-6,87983-24-2,87983-25-3,87983-26-4,100897-23-2,101399-92-2,105761-85-1,105761-86-2
(Z)-7-[(1R,2S,3R,4S)-3-((E)-(R)-3-Hydroxy-4-phenyl-pent-1-enyl)-7-oxa-bicyclo[2.2.1]hept-2-yl]-hept-5-enoic acid methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) LiBr, Et₃N / 1.) CH₂Cl₂, RT, 40 min 2.) RT, overnight

2: CeCl₃*7H₂O, NaBH₄ / tetrahydrofuran; methanol / 2.25 h / -50 - -30 °C

With sodium tetrahydroborate; cerium(III) chloride; triethylamine; lithium bromide; In tetrahydrofuran; methanol;
DOI:10.1021/jm00168a032