6-(2-Aminopropyl)-2,3-dihydrobenzofuran

Base Information

Chemical Name:6-(2-Aminopropyl)-2,3-dihydrobenzofuran
CAS No.:152623-93-3
Molecular Formula:C₁₁H₁₅NO
Molecular Weight:177.246
Hs Code.:2932999099
UNII:O72F3CP4O8
DSSTox Substance ID:DTXSID60934559
Nikkaji Number:J3.334.443K
Wikipedia:6-APDB
Wikidata:Q4641530
ChEMBL ID:CHEMBL124055
Mol file:152623-93-3.mol

Synonyms:6-(2-aminopropyl)-2,3-dihydrobenzofuran;6-NProp-DBF

Suppliers and Price of 6-(2-Aminopropyl)-2,3-dihydrobenzofuran

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 93 raw suppliers

Chemical Property of 6-(2-Aminopropyl)-2,3-dihydrobenzofuran

Chemical Property:

Vapor Pressure:0.00179mmHg at 25°C
Refractive Index:1.565
Boiling Point:292.868 °C at 760 mmHg
Flash Point:134.233 °C
PSA：35.25000
Density:1.088 g/cm³
LogP:2.21150
XLogP3:1.7
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:2
Exact Mass:177.115364102
Heavy Atom Count:13
Complexity:172

Purity/Quality:: 99%, ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC(CC1=CC2=C(CCO2)C=C1)N

Technology Process of 6-(2-Aminopropyl)-2,3-dihydrobenzofuran

There total 7 articles about 6-(2-Aminopropyl)-2,3-dihydrobenzofuran which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 152623-93-3
6-(2-aminopropyl)-2,3-dihydrobenzofuran

: 152623-93-3
1‐(2,3‐dihydro‐1‐benzofuran‐6‐yl)propan‐2‐amine

: 152623-93-3
1‐(2,3‐dihydro‐1‐benzofuran‐6‐yl)propan‐2‐amine

Guidance literature:: With isopropylamine; trifluoroacetic acid; In tetrahydrofuran; methanol; isopropyl alcohol; at 35 ℃; under 103432 Torr; Reagent/catalyst; Solvent; Resolution of racemate; Supercritical conditions;
DOI:10.1002/chir.22701

Reference yield:

: 152623-93-3
6-(2-aminopropyl)-2,3-dihydrobenzofuran

: 152623-93-3
1‐(2,3‐dihydro‐1‐benzofuran‐6‐yl)propan‐2‐amine

: 152623-93-3
1‐(2,3‐dihydro‐1‐benzofuran‐6‐yl)propan‐2‐amine

Guidance literature:: With isopropylamine; trifluoroacetic acid; In tetrahydrofuran; methanol; isopropyl alcohol; at 35 ℃; under 103432 Torr; Reagent/catalyst; Solvent; Resolution of racemate; Supercritical conditions;
DOI:10.1002/chir.22701

Reference yield:

: 17862-85-0
3-methoxyamphetamine

: 152623-93-3
6-(2-aminopropyl)-2,3-dihydrobenzofuran

Guidance literature:: Multi-step reaction with 5 steps

1: 1.) Et₃N / 1.) CH₂Cl₂, 10 min, 2.) CH₂Cl₂, RT, 1.5 h

2: 3.5 g / AlCl₃ / 1,2-dichloro-ethane / 4 h / 45 °C

3: 1.) BBr₃, 2.) NaOAc / 1.) CH₂Cl₂, -78 deg C to RT, 12 h, 2.) CH₃OH, reflux, 1.5 h

4: H₂ / 20percent PdOH/C / ethanol / 12 h / 2689.2 Torr

5: 2N KOH / propan-2-ol / 5 h / Heating

With potassium hydroxide; aluminium trichloride; hydrogen; sodium acetate; boron tribromide; triethylamine; PdOH/C; In ethanol; 1,2-dichloro-ethane; isopropyl alcohol;
DOI:10.1021/jm00075a027