8-fluoro-5-(4-fluorophenyl)-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indole

Base Information

Chemical Name:8-fluoro-5-(4-fluorophenyl)-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indole
CAS No.:58038-68-9
Molecular Formula:C17H14F2N2
Molecular Weight:284.308
Hs Code.:
ChEMBL ID:CHEMBL59582
DSSTox Substance ID:DTXSID30504945

Synonyms:CHEMBL59582;8-fluoro-5-(4-fluorophenyl)-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indole;58038-68-9;SCHEMBL10378638;DTXSID30504945;KSTQTBPDPFIZBT-UHFFFAOYSA-N;BDBM50225840;8-Fluoro-5-(p-fluorophenyl)-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indole

Suppliers and Price of 8-fluoro-5-(4-fluorophenyl)-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indole

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 8-fluoro-5-(4-fluorophenyl)-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indole

Chemical Property:

Melting Point:127-128 °C
Boiling Point:432.9±45.0 °C(Predicted)
PSA：16.96000
Density:1.33±0.1 g/cm3(Predicted)
LogP:3.88320
XLogP3:3.3
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:1
Exact Mass:284.11250478
Heavy Atom Count:21
Complexity:370

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:C1CNCC2=C1N(C3=C2C=C(C=C3)F)C4=CC=C(C=C4)F

Technology Process of 8-fluoro-5-(4-fluorophenyl)-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indole

There total 6 articles about 8-fluoro-5-(4-fluorophenyl)-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 41.0%

: 58038-67-8
2-carbethoxy-8-fluoro-5-(4-fluorophenyl)-1,2,3,4-tetrahydro-γ-carboline

: 58038-68-9
8-fluoro-5-(4-fluorophenyl)-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indole

Guidance literature:: With potassium hydroxide; water; In ethanol; for 23h; Heating;
DOI:10.1021/jm00180a011

Reference yield:

: 58038-66-7
2-carbethoxy-8-fluoro-2,3,4,5-tetrahydro-1H-pyrido<4,3-b>indole

: 58038-68-9
8-fluoro-5-(4-fluorophenyl)-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indole

Guidance literature:: Multi-step reaction with 2 steps

1: Cu₂Br₂, Na₂CO₃, N-methyl-2-pyrrolidinone / Heating

2: KOH / ethanol; H₂O; methanol / Heating

With 1-methyl-pyrrolidin-2-one; copper(I) bromide; potassium hydroxide; sodium carbonate; In methanol; ethanol; water;
DOI:10.1021/jm00393a023

Reference yield:

: 460-00-4
1-Bromo-4-fluorobenzene

: 58038-68-9
8-fluoro-5-(4-fluorophenyl)-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indole

Guidance literature:: Multi-step reaction with 2 steps

1: Cu₂Br₂, Na₂CO₃, N-methyl-2-pyrrolidinone / Heating

2: KOH / ethanol; H₂O; methanol / Heating

With 1-methyl-pyrrolidin-2-one; copper(I) bromide; potassium hydroxide; sodium carbonate; In methanol; ethanol; water;
DOI:10.1021/jm00393a023