(E)-3-Cyclopropyl-acrylic acid ethyl ester

Base Information

• Chemical Name: (E)-3-Cyclopropyl-acrylic acid ethyl ester
• CAS No.: 5808-99-1
• Molecular Formula: C₈H₁₂O₂
• Molecular Weight: 140.182
• Hs Code.: 2916200090
• European Community (EC) Number: 860-711-4,695-630-1
• Nikkaji Number: J1.154.961F,J980.034D
• Mol file: 5808-99-1.mol

Synonyms:21014-26-6;(E)-3-Cyclopropyl-acrylic acid ethyl ester;Ethyl 3-cyclopropylacrylate;Ethyl (E)-3-cyclopropylprop-2-enoate;ETHYL (2E)-3-CYCLOPROPYLPROP-2-ENOATE;(E)-ethyl 3-cyclopropylacrylate;ethyl (E)-3-cyclopropylacrylate;ethyl (2E)-3-cyclopropylacrylate;5808-99-1;3-Cyclopropylpropenoic acid ethyl ester;(E)-ethyl3-cyclopropylacrylate;SCHEMBL7512241;HXBCPBSHJYHXQV-AATRIKPKSA-N;Ethyl 3-cyclopropylacrylate, 97%;WAA01426;MFCD11506679;AKOS006325034;(E)-Cyclopropaneacrylic acid ethyl ester;AS-54877;CS-0055981;CS-0198295;W10675;EN300-1455948

Chemical Property of (E)-3-Cyclopropyl-acrylic acid ethyl ester

Chemical Property:

• Refractive Index: n20/D1.475
• PSA: 26.30000
• Density: 0.961 g/mL at 25 °C
• LogP: 1.51570
• Storage Temp.: 2-8°C
• XLogP3: 1.9
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 4
• Exact Mass: 140.083729621
• Heavy Atom Count: 10
• Complexity: 145

Purity/Quality:

97% ^*data from raw suppliers

3-?Cyclopropyl-?2-?propenoicAcidEthylEster ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCOC(=O)C=CC1CC1
• Isomeric SMILES: CCOC(=O)/C=C/C1CC1
• Uses: 3-Cyclopropyl-2-propenoic Acid Ethyl Ester is used as a reactant for the preparation of quinolizinone- and pyridopyrimidinonecarboxylates as antibacterials. 3-Cyclopropyl-2-propenoic acid ethyl ester is also used in the preparation of Carbomoylcholine analogs.

Technology Process of (E)-3-Cyclopropyl-acrylic acid ethyl ester

There total 16 articles about (E)-3-Cyclopropyl-acrylic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

diethoxyphosphoryl-acetic acid ethyl ester (867-13-0) + Cyclopropanecarboxaldehyde (1489-69-6) → ethyl 3-cyclopropaneprop-2-enoate (21014-26-6,5808-99-1)

Guidance literature:

diethoxyphosphoryl-acetic acid ethyl ester; With sodium hydride; In tetrahydrofuran; at 0 - 20 ℃;

Cyclopropanecarboxaldehyde; In tetrahydrofuran; at 20 ℃; for 2h;

Reference yield: 93.8%

diethoxyphosphoryl-acetic acid ethyl ester (867-13-0) + Cyclopropanecarboxaldehyde (1489-69-6) → ethyl 3-(3-cyclopropyl)propenoate (5808-99-1)

Guidance literature:

diethoxyphosphoryl-acetic acid ethyl ester; With sodium hydride; In tetrahydrofuran; mineral oil; at 0 ℃; for 0.5h;

Cyclopropanecarboxaldehyde; In tetrahydrofuran; N,N-dimethyl-formamide; mineral oil; at 0 - 20 ℃;

Reference yield: 86.0%

Cyclopropylmethanol (2516-33-8) + ethyl (triphenylphosphoranylidene)acetate (1099-45-2) → ethyl 3-cyclopropaneprop-2-enoate (21014-26-6,5808-99-1)

Guidance literature:

With manganese(IV) oxide; In toluene; for 4h; Heating;

DOI:10.1039/a903980e

upstream raw materials:

diethyl 2-(tetrahydrofuran-2-yl)malonate

ethyl sodiodiethylphosphonoacetate

Cyclopropanecarboxaldehyde

diethoxyphosphoryl-acetic acid ethyl ester

Downstream raw materials:

ethyl 3-cyclopropylacrylate