2-AMINO-4-CYCLOPROPYLTHIOPHENE-3-CARBONITRILE

Base Information

• Chemical Name: 2-AMINO-4-CYCLOPROPYLTHIOPHENE-3-CARBONITRILE
• CAS No.: 58124-28-0
• Molecular Formula: C8H8N2S
• Molecular Weight: 164.23
• Hs Code.: 2934999090
• Mol file: 58124-28-0.mol

Synonyms:

Chemical Property of 2-AMINO-4-CYCLOPROPYLTHIOPHENE-3-CARBONITRILE

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

2-Amino-4-cyclopropylthiophene-3-carbonitrile ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Uses: 2-Amino-4-cyclopropylthiophene-3-carbonitrile is a reagent used in the synthesis of a novel class of CCR3 modulators as a potential treatment for weight disorders as well as congnitive disorders.

Technology Process of 2-AMINO-4-CYCLOPROPYLTHIOPHENE-3-CARBONITRILE

There total 2 articles about 2-AMINO-4-CYCLOPROPYLTHIOPHENE-3-CARBONITRILE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 21.0%

2-(1-cyclopropylethylidene)malononitrile (17407-30-6) → 4-cyclopropyl-3-cyano-2-aminothiophene (58124-28-0)

Guidance literature:

With sulfur; diethylamine; In ethanol; at 50 - 60 ℃;

DOI:10.1007/BF00764665

Reference yield:

Cyclopropyl methyl ketone (765-43-5) → 4-cyclopropyl-3-cyano-2-aminothiophene (58124-28-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 51 percent

2: 21 percent / sulfur, diethylamine, / ethanol / 70 - 75 °C

With sulfur; diethylamine; In ethanol;

DOI:10.1007/BF00479336

Reference yield:

4-cyclopropyl-3-cyano-2-aminothiophene (58124-28-0) → 8-[1-(2-Bromo-phenyl)-meth-(E)-ylidene]-3-cyclopropyl-7,8-dihydro-6H-pyrrolo[1,2-a]thieno[2,3-d]pyrimidin-4-ylideneamine

Guidance literature:

Multi-step reaction with 3 steps

1: Heating

2: Heating

3: POCl₃

With trichlorophosphate;

DOI:10.1016/j.bmcl.2004.11.039

upstream raw materials:

2-(1-cyclopropylethylidene)malononitrile

Cyclopropyl methyl ketone

Downstream raw materials:

(2-Bromo-phenyl)-(3-cyclopropyl-4-imino-4,6,7,8-tetrahydro-pyrrolo[1,2-a]thieno[2,3-d]pyrimidin-8-yl)-methanol

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