5-Aminosalicylaldehyde

Base Information

• Chemical Name: 5-Aminosalicylaldehyde
• CAS No.: 58186-71-3
• Molecular Formula: C7H7NO2
• Molecular Weight: 137.138
• DSSTox Substance ID: DTXSID00429479
• Nikkaji Number: J1.899.851C
• Wikidata: Q27109311
• Metabolomics Workbench ID: 53766
• Mol file: 58186-71-3.mol

Synonyms:5-Aminosalicylaldehyde;5-Amino-2-hydroxybenzaldehyde;58186-71-3;Benzaldehyde, 5-amino-2-hydroxy-;5-AMINO SALICYLALDEHYDE;2-Hydroxy-5-aminobenzaldehyde;SCHEMBL6380412;CHEBI:20550;DTXSID00429479;AKOS006342430;MB01352;BB 0262665;CS-0370520;Q27109311

Chemical Property of 5-Aminosalicylaldehyde

Chemical Property:

• Melting Point: 286 °C
• Boiling Point: 298.2±30.0 °C(Predicted)
• PKA: 8.43±0.18(Predicted)
• PSA: 63.32000
• Density: 1.347±0.06 g/cm3(Predicted)
• LogP: 1.36810
• XLogP3: 0.9
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 1
• Exact Mass: 137.047678466
• Heavy Atom Count: 10
• Complexity: 127

Purity/Quality:

99%+ ^*data from raw suppliers

5-AMINO SALICYLALDEHYDE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC(=C(C=C1N)C=O)O

Technology Process of 5-Aminosalicylaldehyde

There total 5 articles about 5-Aminosalicylaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

5-Aminosalicylic Acid (89-57-6) + metaboric acid (13460-50-9) → pimelaldehyde (53185-69-6) + 5-aminosalicylic aldehyde (58186-71-3)

Guidance literature:

Reference yield:

5-Nitrosalicylaldehyde (97-51-8) → 5-aminosalicylic aldehyde (58186-71-3)

Guidance literature:

With Mo₄O₄N₃; hydrazine hydrate; In ethanol; at 30 ℃; for 1h; chemoselective reaction; Green chemistry;

DOI:10.1039/d1gc02647j

Reference yield:

4-[(3-formyl-4-hydroxyphenyl)diazenyl]benzenesulfonic acid (16358-43-3) → 5-aminosalicylic aldehyde (58186-71-3)

Guidance literature:

With hydrogen sulfide; sodium carbonate; at 60 - 70 ℃;

upstream raw materials:

5-Aminosalicylic Acid

4-[(3-formyl-4-hydroxyphenyl)diazenyl]benzenesulfonic acid

hydrogen sulfide

metaboric acid

Downstream raw materials:

5-amino-2-hydroxy-benzaldehyde phenylhydrazone

5-amino-2-hydroxy-benzaldehyde-((E)-O-methyl oxime )

Refernces