4-(4-Methoxyphenyl)benzaldehyde

Base Information

• Chemical Name: 4-(4-Methoxyphenyl)benzaldehyde
• CAS No.: 52988-34-8
• Molecular Formula: C14H12O2
• Molecular Weight: 212.248
• Hs Code.: 2912490090
• European Community (EC) Number: 692-469-9
• DSSTox Substance ID: DTXSID80362754
• Nikkaji Number: J1.563.581I
• Wikidata: Q72489358
• Mol file: 52988-34-8.mol

Synonyms:52988-34-8;4-(4-Methoxyphenyl)benzaldehyde;4'-methoxybiphenyl-4-carbaldehyde;4'-Methoxy-[1,1'-biphenyl]-4-carbaldehyde;4'-methoxybiphenyl-4-carboxaldehyde;4'-Methoxy-biphenyl-4-carboxaldehyde;4'-methoxy[1,1'-biphenyl]-4-carbaldehyde;4'-Methoxy-biphenyl-4-carbaldehyde;4'-methoxy-[1,1'-biphenyl]-4-carboxaldehyde;4-(4-methoxy)benzaldehyde;SCHEMBL6351;JTTIGLYPLMYHAT-UHFFFAOYSA-;DTXSID80362754;4-(4'-methoxyphenyl)benzaldehyde;4-methoxybiphenyl-4'-carboxaldehyde;AMY33276;AR2042;MFCD01862517;4-formyl-4'-methoxy-1,1'-biphenyl;AKOS000301047;4-(4-methoxyphenyl)benzaldehyde, 97%;4'-methoxy-1,1'-biphenyl-4-carbaldehyde;4-(4-methoxyphenyl)benzaldehyde, AldrichCPR;BB 0220543;CS-0071999;FT-0640124;EN300-265776;A829338;10Z-0706;J-515614;F9995-0534

Chemical Property of 4-(4-Methoxyphenyl)benzaldehyde

Chemical Property:

• Melting Point: 98-100°C
• Boiling Point: 363.5 °C at 760 mmHg
• Flash Point: 168.2 °C
• PSA: 26.30000
• Density: 1.114 g/cm³
• LogP: 3.17470
• Storage Temp.: Inert atmosphere,Room Temperature
• Sensitive.: Air Sensitive
• XLogP3: 3.4
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 3
• Exact Mass: 212.083729621
• Heavy Atom Count: 16
• Complexity: 211

Purity/Quality:

98%,99%, ^*data from raw suppliers

4''-Methoxybiphenyl-4-carboxaldehyde ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=CC=C(C=C1)C2=CC=C(C=C2)C=O
• Uses: 4''-Methoxybiphenyl-4-carboxaldehyde acts as a reagent in the research studies involving the use of aryliden-methyloxazolones as reversible MAGL inhibitors for cancer treatment.

Technology Process of 4-(4-Methoxyphenyl)benzaldehyde

There total 7 articles about 4-(4-Methoxyphenyl)benzaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.0%

7-(4-methoxyphenyl)cyclohepta-1,3,5-triene (29304-87-8) → 2-(4-methoxyphenyl)benzaldehyde (16064-04-3) + 4-(4'-methoxyphenyl)benzaldehyde (52988-34-8)

Guidance literature:

With 2-(di-tert-butylphosphino)-1,1'-biphenylgold(I) chloride; oxygen; sodium tetrakis[(3,5-di-trifluoromethyl)phenyl]borate; Nitrosobenzene; copper(l) chloride; In dichloromethane; at 23 ℃; Inert atmosphere; Molecular sieve;

DOI:10.1021/acs.orglett.1c01857

Reference yield: 33.0%

6-(4-methoxyphenyl)bicyclo[3.2.0]hept-2-en-6-ol (1018955-96-8) → 2-(4-methoxyphenyl)benzaldehyde (16064-04-3) + 4-methoxylbiphenyl (613-37-6) + 4-(4'-methoxyphenyl)benzaldehyde (52988-34-8) + 4'-methoxy-[1,1'-biphenyl]-3-carbaldehyde (118350-17-7)

Guidance literature:

6-(4-methoxyphenyl)bicyclo[3.2.0]hept-2-en-6-ol; With toluene-4-sulfonic acid; In benzene; for 3h; Reflux;

With chromium(VI) oxide; acetic acid; In water; at 10 - 20 ℃; for 23h;

DOI:10.1002/hlca.200890058

Reference yield:

phenyl(triphenyl-λ5-phosphanyl)gold + p-methoxyphenyl(triphenylphosphine)gold(I) (127591-24-6) + 4-bromo-benzaldehyde (1122-91-4) → 4-(4'-methoxyphenyl)benzaldehyde (52988-34-8) + 4-Phenylbenzaldehyde (3218-36-8)

Guidance literature:

With dichlorobis(tricyclohexylphosphine)nickel(II); In benzene; at 25 ℃; for 2h;

DOI:10.1021/om200060x

upstream raw materials:

6-(4-methoxyphenyl)bicyclo[3.2.0]hept-2-en-6-ol

p-methoxyphenyl(triphenylphosphine)gold(I)

4-bromo-benzaldehyde

[4-(trifluoromethyl)phenyl](triphenylphosphine)gold(I)

Downstream raw materials:

N-(2-(tert-butylamino)-1-(4'-methoxy-[1,1'-biphenyl]-4-yl)-2-oxoethyl)-4-methoxy-N-(pyridin-2-ylmethyl)benzamide

N-(tert-butyl)-N-(2-(tert-butylamino)-1-(4'-methoxy-[1,1'-biphenyl]-4-yl)-2-oxoethyl)-3-(3,4-dihydroxyphenyl)propanamide

(S)-2-{(R)-hydroxy[4'-methoxy-1,1'-biphenyl-4-yl]methyl}cyclopentanone

Refernces

• 1、 Suzaki, Yuji,Saito, Takashi,Osakada, Kohtaro. "Catalytic and stoichiometric reactions of Arylpalladium(II) complexes bearing a trans-chelating dinitrogen ligand with arylboronic acids". . . Retrieved 2020/01/30.
• 2、 Ceylan, Mustafa,Findik, Esra,Secen, Hasan. "An oxidative rearrangement of 6-phenylbicyclo[3.2.0]heptan-6-ol to 1,1′-biphenyl-carbaldehydes: A mechanistic study". experimental part. p. 559 - 568. Retrieved 2009/02/07.