1-PHENYL-1H-INDOLE-2-CARBOXYLIC ACID

Base Information

• Chemical Name: 1-PHENYL-1H-INDOLE-2-CARBOXYLIC ACID
• CAS No.: 58386-33-7
• Molecular Formula: C15H11NO2
• Molecular Weight: 237.258
• Hs Code.: 2933990090
• Mol file: 58386-33-7.mol

Synonyms:l-phenylindole-2-carboxylic acid;1-Phenyl-indol-2-carbonsaeure;1-Phenyl-1H-indole-2-carboxylic acid;F1901-0148;N-phenylindole-2-carboxylic acid;acido 1-fenilindolo-2-carbossilico;1-phenyl-indole-2-carboxylic acid;

Chemical Property of 1-PHENYL-1H-INDOLE-2-CARBOXYLIC ACID

Chemical Property:

• PSA: 42.23000
• LogP: 3.32870

Purity/Quality:

NLT 98% ^*data from raw suppliers

1-Phenyl-1H-indole-2-carboxylic acid 95%+ ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-PHENYL-1H-INDOLE-2-CARBOXYLIC ACID

There total 7 articles about 1-PHENYL-1H-INDOLE-2-CARBOXYLIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

1-phenyl-1H-indole-2-carboxylic acid methyl ester (78945-61-6) → 1-phenylindole-2-carboxylic acid (58386-33-7)

Guidance literature:

With sodium hydroxide; In tetrahydrofuran; methanol; at 120 ℃; for 22h;

DOI:10.1021/jm501330g

Reference yield: 71.0%

bromobenzene (108-86-1,52753-63-6) + Indole-2-carboxylic acid (1477-50-5,1228050-17-6) → 1-phenylindole-2-carboxylic acid (58386-33-7)

Guidance literature:

With potassium carbonate; copper(II) oxide; In N,N-dimethyl-formamide; Heating;

DOI:10.1016/j.tetlet.2004.05.133

Reference yield:

indole-2-carboxylic acid methyl ester (1202-04-6) → 1-phenylindole-2-carboxylic acid (58386-33-7)

Guidance literature:

Multi-step reaction with 2 steps

1: copper(l) iodide; trans-N,N'-dimethylcyclohexane-1,2-diamine; potassium phosphate / toluene / 22 h / 120 °C / Sealed tube

2: sodium hydroxide / tetrahydrofuran; methanol / 22 h / 120 °C

With potassium phosphate; copper(l) iodide; trans-N,N'-dimethylcyclohexane-1,2-diamine; sodium hydroxide; In tetrahydrofuran; methanol; toluene;

DOI:10.1021/jm501330g

upstream raw materials:

2-diphenylhydrazono-propionic acid

bromobenzene

Indole-2-carboxylic acid

indole-2-carboxylic acid methyl ester

Downstream raw materials:

1-phenyl-1H-indole-2-carboxylic acid methyl ester

1-phenyl-indole-2,3-dione

1-phenyl-1H-indole-2-carboxylic acid 2-pyrrolidin-1-yl-ethyl ester

3,3-dibromo-1-phenyl-indolin-2-one

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