1-(5-Phenyl-1,2,4-oxadiazol-3-yl)piperidine

Base Information

• Chemical Name: 1-(5-Phenyl-1,2,4-oxadiazol-3-yl)piperidine
• CAS No.: 58476-83-8
• Molecular Formula: C13H15N3O
• Molecular Weight: 229.282
• DSSTox Substance ID: DTXSID80489950
• Nikkaji Number: J3.062.975B
• Wikidata: Q82333507
• Mol file: 58476-83-8.mol

Synonyms:58476-83-8;1-(5-Phenyl-1,2,4-oxadiazol-3-yl)piperidine;DTXSID80489950

Chemical Property of 1-(5-Phenyl-1,2,4-oxadiazol-3-yl)piperidine

Chemical Property:

• XLogP3: 3.1
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 2
• Exact Mass: 229.121512110
• Heavy Atom Count: 17
• Complexity: 237

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: C1CCN(CC1)C2=NOC(=N2)C3=CC=CC=C3

Technology Process of 1-(5-Phenyl-1,2,4-oxadiazol-3-yl)piperidine

There total 9 articles about 1-(5-Phenyl-1,2,4-oxadiazol-3-yl)piperidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

piperidine (110-89-4) + 3-(Benzoylamino)-4-methylfurazan (102140-71-6) → 5-phenyl-3-(1-piperidyl)-1,2,4-oxadiazole (58476-83-8) + acetonitrile (75-05-8,26809-02-9)

Guidance literature:

In methanol; for 5h; Irradiation;

Reference yield:

C14H18N2OS (1338831-69-8) → 5-phenyl-3-(1-piperidyl)-1,2,4-oxadiazole (58476-83-8)

Guidance literature:

With hydroxylamine; In methanol; at 0 - 20 ℃; regioselective reaction;

DOI:10.1016/j.tetlet.2011.09.048

Reference yield:

N-benzoyl-piperidine-1-carboximidic acid chloroamide (58476-82-7) → 5-phenyl-3-(1-piperidyl)-1,2,4-oxadiazole (58476-83-8)

Guidance literature:

With sodium hydroxide; In diethyl ether;

DOI:10.1246/bcsj.49.3607

upstream raw materials:

piperidine

3-trichloromethyl-5-phenyl-1,2,4-oxadiazole

N-benzoyl-piperidine-1-carboximidic acid chloroamide

3-(Benzoylamino)-4-methylfurazan