2-Methylbutane-1,2,3,4,-tetrol

Base Information

• Chemical Name: 2-Methylbutane-1,2,3,4,-tetrol
• CAS No.: 42933-13-1
• Molecular Formula: C5H12 O4
• Molecular Weight: 136.148
• Hs Code.: 2905499000
• European Community (EC) Number: 256-006-0
• DSSTox Substance ID: DTXSID901308143
• Nikkaji Number: J310.007C
• Wikidata: Q105027989
• Mol file: 42933-13-1.mol

Synonyms:42933-13-1;2-Methylbutane-1,2,3,4,-tetrol;2-methyl-1,2,3,4-butanetetrol;2-methylbutane-1,2,3,4-tetrol;EINECS 256-006-0;1,2,3,4-Butanetetrol, 2-methyl-, (2R,3R)-;3-Methylerythritol;2-C-Methylerythritol;SCHEMBL17867170;DTXSID901308143;2-Methylbutane-1,2,3,4-tetraol;2-methyl-butane-1,2,3,4-tetraol;EN300-23015546

Chemical Property of 2-Methylbutane-1,2,3,4,-tetrol

Chemical Property:

• Vapor Pressure: 6.46E-07mmHg at 25°C
• Boiling Point: 368.1°Cat760mmHg
• PKA: 13?+-.0.29(Predicted)
• Flash Point: 193.1°C
• PSA: 80.92000
• Density: 1.341g/cm³
• LogP: -1.91710
• XLogP3: -2.2
• Hydrogen Bond Donor Count: 4
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 3
• Exact Mass: 136.07355886
• Heavy Atom Count: 9
• Complexity: 85

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(CO)(C(CO)O)O

Technology Process of 2-Methylbutane-1,2,3,4,-tetrol

There total 61 articles about 2-Methylbutane-1,2,3,4,-tetrol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

4-benzyl-2-C-methyl-D-erythritol (444183-85-1) → 2-C-methyl-D-erythritol (42933-13-1,77646-71-0,93921-83-6,93921-84-7,58698-37-6)

Guidance literature:

With hydrogen; 10percent Pd/C; In methanol; for 3h;

DOI:10.1021/jo020168y

Reference yield: 100.0%

(2R,3S)-4-Benzyloxy-3-methyl-butane-1,2,3-triol (310888-00-7) → 2-C-methyl-D-erythritol (42933-13-1,77646-71-0,93921-83-6,93921-84-7,58698-37-6)

Guidance literature:

With hydrogen; palladium on activated charcoal;

DOI:10.1016/S0040-4039(00)01296-X

Reference yield: 91.0%

C11H20O4 (1092965-07-5) → 2-C-methyl-D-erythritol (42933-13-1,77646-71-0,93921-83-6,93921-84-7,58698-37-6)

Guidance literature:

With water; trifluoroacetic acid; In dichloromethane; at 0 ℃; for 3.5h;

DOI:10.1016/j.tetasy.2008.09.002

upstream raw materials:

2,3-O-isopropylidene-2-C-methyl-L-erythritol

(6R,7R,15S)-15-[(S)-1-Hydroxy-2-(4-methoxy-benzyloxy)-ethyl]-15-methyl-1,8,13,16-tetraoxa-dispiro[5.0.5.4]hexadecan-14-one

(2S,3R)-dimethyl 2,3-dihydroxy-2-methylbutanedioate

(2R,3R)-ethyl 2,3-dihydroxy-4-(4-methoxybenzyloxy)-3-methylbutanoate

Downstream raw materials:

1,2,3,4-tetra-O-benzoyl-3-C-methyl-L-threitol

1,2,3,4-tetra-O-benzoyl-3-C-methylerythritol

Refernces

• 1、 Sharma, Anubha,Das, Priyadip,Chattopadhyay, Subrata. "Concise asymmetric syntheses of the (+)-2-C-methyltetritol isomers". . p. 2167 - 2170. Retrieved 2008.
• 2、 Gadetskaya, Anastassiya V.,Mohamed, Shaymaa M.,Tarawneh, Amer H.,Mohamed, Nesma M.,Ma, Guoyi,Ponomarev, Boris N.,Zhusupova, Galiya E.,Cantrell, Charles L.,Cutler, Stephen J.,Ross, Samir A.. "Phytochemical characterization and biological activity of secondary metabolites from three Limonium species". . p. 2743 - 2750. Retrieved 2017.
• 3、 Sagner, Silvia,Eisenreich, Wolfgang,Fellermeier, Monika,Latzel, Christoph,Bacher, Adelbert,Zenk, Meinhart H.. "Biosynthesis of 2-C-methyl-D-erythritol in plants by rearrangement of the terpenoid precursor, 1-deoxy-D-xylulose 5-phosphate". . p. 2091 - 2094. Retrieved 1998.