L-Proline, 1-[N-[(1,1-dimethylethoxy)carbonyl]-L-seryl]-

Base Information

Chemical Name:L-Proline, 1-[N-[(1,1-dimethylethoxy)carbonyl]-L-seryl]-
CAS No.:58810-15-4
Molecular Formula:C13H22N2O6
Molecular Weight:
Hs Code.:
DSSTox Substance ID:DTXSID40454801
Nikkaji Number:J2.851.375E
Wikidata:Q82276545

Synonyms:58810-15-4;L-Proline, 1-[N-[(1,1-dimethylethoxy)carbonyl]-L-seryl]-;SCHEMBL22070275;DTXSID40454801

Suppliers and Price of L-Proline, 1-[N-[(1,1-dimethylethoxy)carbonyl]-L-seryl]-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of L-Proline, 1-[N-[(1,1-dimethylethoxy)carbonyl]-L-seryl]-

Chemical Property:

XLogP3:-0.4
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:6
Exact Mass:302.14778643
Heavy Atom Count:21
Complexity:417

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC(C)(C)OC(=O)NC(CO)C(=O)N1CCCC1C(=O)O
Isomeric SMILES:CC(C)(C)OC(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)O

Technology Process of L-Proline, 1-[N-[(1,1-dimethylethoxy)carbonyl]-L-seryl]-

There total 3 articles about L-Proline, 1-[N-[(1,1-dimethylethoxy)carbonyl]-L-seryl]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 61243-17-2
Boc-Ser-Pro-OBn

: 58810-15-4
(2S)-1-[(2S)-2-[(tert-butoxycarbonyl)amino]-3-hydroxypropanoyl]pyrrolidine-2-carboxylic acid

Guidance literature:: With palladium 10% on activated carbon; hydrogen; In methanol;
DOI:10.1016/j.tet.2010.05.040

Reference yield: 33.0%

: 174709-51-4
Boc-Ser-Pro-OMe

: 58810-15-4
(2S)-1-[(2S)-2-[(tert-butoxycarbonyl)amino]-3-hydroxypropanoyl]pyrrolidine-2-carboxylic acid

Guidance literature:: With water; lithium hydroxide; In tetrahydrofuran; at 20 ℃; for 2h; Inert atmosphere;

Reference yield:

: 3262-72-4
(S)-N-(tert-butoxycarbonyl)serine

: 2577-48-2
methyl (2S)-pyrrolidine carboxylate

: 58810-15-4
(2S)-1-[(2S)-2-[(tert-butoxycarbonyl)amino]-3-hydroxypropanoyl]pyrrolidine-2-carboxylic acid

Guidance literature:: Multi-step reaction with 2 steps

1: N-ethyl-N,N-diisopropylamine; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate / N,N-dimethyl-formamide / 2 h / 20 - 25 °C / Inert atmosphere

2: lithium hydroxide; water / tetrahydrofuran / 2 h / 20 °C / Inert atmosphere

With water; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; lithium hydroxide; In tetrahydrofuran; N,N-dimethyl-formamide;