Technology Process of L-Proline, 1-[1-[N-[(1,1-dimethylethoxy)carbonyl]-L-valyl]-L-prolyl]-,
phenylmethyl ester
There total 1 articles about L-Proline, 1-[1-[N-[(1,1-dimethylethoxy)carbonyl]-L-valyl]-L-prolyl]-,
phenylmethyl ester which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
4-methyl-morpholine; sulfuric acid; chloroformic acid ethyl ester;
Multistep reaction;
1.) ethyl acetate 2.) THF, DMF, 0 deg C, 1h than room temp.,;
- Guidance literature:
-
With
hydrogenchloride;
In
1,4-dioxane;
for 1h;
Ambient temperature;
- Guidance literature:
-
Multi-step reaction with 7 steps
1: 95 percent / 4.5 N HCl / dioxane / 1 h / Ambient temperature
2: 1.) 1 N sulfuric acid 2.) ECF, NMM / 1.) ethyl acetate 2.) THF, DMF, 0 deg C, 1 h than room temp.
3: 93 percent / 4.5 N HCL / dioxane / 1 h / Ambient temperature
4: 1.) 1 N sulfuric acid 2.) ECF, NMM / 1.) ethyl acetate 2.) THF, DMF, 0 deg C, 1 h than room temp.
5: 73 percent / H2 / Palladium black / methanol / 18 h
6: 1.) 1 N sulfuric acid 2.) ECF, NMM / 1.) ethyl acetate 2.) THF, DMF, 0 deg C, 1 h than room temp.
7: 96 percent / 4.5 N HCl / dioxane; formic acid / 0.5 h / 0 °C
With
4-methyl-morpholine; hydrogenchloride; sulfuric acid; hydrogen; chloroformic acid ethyl ester;
palladium;
In
1,4-dioxane; methanol; formic acid;
