4,8-Dimethyl-2-(2-methyl-1-propenyl)-1-oxaspiro[4.5]dec-7-ene

Base Information

• Chemical Name: 4,8-Dimethyl-2-(2-methyl-1-propenyl)-1-oxaspiro[4.5]dec-7-ene
• CAS No.: 38970-57-9
• Molecular Formula: C15H24O
• Molecular Weight: 0
• Hs Code.: 2932999099
• Mol file: 38970-57-9.mol

Synonyms:Bisabolenoxid;1-Oxaspiro(4.5)dec-7-ene,4,8-dimethyl-2-(2-methyl-1-propenyl);4,8-dimethyl-2-(2-methyl-propenyl)-1-oxa-spiro[4.5]dec-7-ene;bisabolene oxide;4,8-dimethyl-2-(2-methyl-1-propenyl)-1-oxaspiro(4.5)dec-7-ene;

Chemical Property of 4,8-Dimethyl-2-(2-methyl-1-propenyl)-1-oxaspiro[4.5]dec-7-ene

Chemical Property:

• PSA: 9.23000
• LogP: 4.24660

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4,8-Dimethyl-2-(2-methyl-1-propenyl)-1-oxaspiro[4.5]dec-7-ene

There total 6 articles about 4,8-Dimethyl-2-(2-methyl-1-propenyl)-1-oxaspiro[4.5]dec-7-ene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 39.0%

6-(1-hydroxy-4-methyl-3-cyclohexen-1-yl)-2-methyl-2-hepten-4-ol (94607-54-2) → bisabolene oxide (38970-57-9)

Guidance literature:

With p-toluenesulfonyl chloride; In pyridine; at 0 - 25 ℃; for 24h;

DOI:10.1016/S0040-4020(01)91487-5

Reference yield:

4-methyl-3-cyclohexen-1-one (5259-65-4) → bisabolene oxide (38970-57-9)

Guidance literature:

Multi-step reaction with 6 steps

1: 1.) Mg, I₂ / 1.) THF, 15 grad C, 2 h; 2.) heating, 1 h

2: 1.) BH₃; 2.) 2 N NaOH, 30 percent H₂O₂, K₂CO₃ / 1.) THF, 0 grad C, 3 h; 2.) 1 h

3: 59 percent / pyridinium chlorochromate / CH₂Cl₂ / 2 h

4: 1.) 20 percent DIBAH; 2.) ice, acetic acid / 1.) toluene, -78 grad C, 3 h; 2.) 0 grad C

5: 1.) Mg, I₂ / 1.) THF, 75 grad C, 1 h; 2.) THF, heating, 24 h

6: 39 percent / tosyl chloride / pyridine / 24 h / 0 - 25 °C

With sodium hydroxide; Methamphetamin; borane; dihydrogen peroxide; iodine; diisobutylaluminium hydride; potassium carbonate; magnesium; acetic acid; p-toluenesulfonyl chloride; pyridinium chlorochromate; In pyridine; dichloromethane;

DOI:10.1016/S0040-4020(01)91487-5

Reference yield:

4-Methyl-1-(3-hydroxy-1-methylpropyl)-3-cyclohexen-1-ol (94607-66-6,94607-82-6,106035-77-2,106035-78-3) → bisabolene oxide (38970-57-9)

Guidance literature:

Multi-step reaction with 4 steps

1: 59 percent / pyridinium chlorochromate / CH₂Cl₂ / 2 h

2: 1.) 20 percent DIBAH; 2.) ice, acetic acid / 1.) toluene, -78 grad C, 3 h; 2.) 0 grad C

3: 1.) Mg, I₂ / 1.) THF, 75 grad C, 1 h; 2.) THF, heating, 24 h

4: 39 percent / tosyl chloride / pyridine / 24 h / 0 - 25 °C

With Methamphetamin; iodine; diisobutylaluminium hydride; magnesium; acetic acid; p-toluenesulfonyl chloride; pyridinium chlorochromate; In pyridine; dichloromethane;

DOI:10.1016/S0040-4020(01)91487-5

upstream raw materials:

6-(1-hydroxy-4-methyl-3-cyclohexen-1-yl)-2-methyl-2-hepten-4-ol

4-methyl-3-cyclohexen-1-one

4-Methyl-1-(3-hydroxy-1-methylpropyl)-3-cyclohexen-1-ol

4,8-Dimethyl-1-oxaspiro<4.5>dec-7-en-2-one