Benzenecarbothioic acid, 4-bromo-, S-(4-chlorophenyl) ester

Base Information

• Chemical Name: Benzenecarbothioic acid, 4-bromo-, S-(4-chlorophenyl) ester
• CAS No.: 59383-65-2
• Molecular Formula: C13H8BrClOS
• Molecular Weight: 327.629
• Mol file: 59383-65-2.mol

Synonyms:

Chemical Property of Benzenecarbothioic acid, 4-bromo-, S-(4-chlorophenyl) ester

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Benzenecarbothioic acid, 4-bromo-, S-(4-chlorophenyl) ester

There total 4 articles about Benzenecarbothioic acid, 4-bromo-, S-(4-chlorophenyl) ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

4,4'-dichlorodiphenyl disulfide (1142-19-4) + 4-bromo-benzaldehyde (1122-91-4) → 4-bromo(thiobenzoic) acid S-(4-chlorophenyl) ester (59383-65-2)

Guidance literature:

With di-tert-butyl peroxide; In neat (no solvent); at 120 ℃; for 12h; Inert atmosphere; Schlenk technique;

DOI:10.1039/c4gc00025k

Reference yield: 72.0%

p-Chlorothiophenol (106-54-7) + 4-chlorobenzoyl chloride (586-75-4) → 4-bromo(thiobenzoic) acid S-(4-chlorophenyl) ester (59383-65-2)

Guidance literature:

With triethylamine; In tetrahydrofuran; at 20 ℃;

DOI:10.1021/jo050110u

Reference yield: 64.0%

4-bromo-benzaldehyde (1122-91-4) + p-Chlorothiophenol (106-54-7) → 4-bromo(thiobenzoic) acid S-(4-chlorophenyl) ester (59383-65-2)

Guidance literature:

With tert.-butylhydroperoxide; copper(l) chloride; In water; at 100 ℃; for 1h; Schlenk technique; Inert atmosphere;

DOI:10.1039/c3gc40946e

upstream raw materials:

<4-Brom-phenacyl>-<4-chlor-phenyl>-sulfid

p-Chlorothiophenol

4-chlorobenzoyl chloride

4-bromo-benzaldehyde

Downstream raw materials:

(4-bromophenyl)(3,5-dimethylphenyl)methanone

4-bromo-4'-methoxybenzophenone

Refernces

• 1、 Yi, Chih-Lun,Huang, Yu-Ting,Lee, Chin-Fa. "Synthesis of thioesters through copper-catalyzed coupling of aldehydes with thiols in water". . p. 2476 - 2484. Retrieved 2013/09/12.
• 2、 GROEBEL. "ON THE NEIGHBORING GROUP EFFECT OF SULFUR ATOMS.". . p. 522 - 527. Retrieved 2007/10/15.