2,4-Hexadecadienoic acid, (E,E)-

Base Information

• Chemical Name: 2,4-Hexadecadienoic acid, (E,E)-
• CAS No.: 59404-48-7
• Molecular Formula: C16H28O2
• Molecular Weight: 252.397
• Mol file: 59404-48-7.mol

Synonyms:hexadeca-2t,4t-dienoic acid;hexadecadienoic acid;hexadecadieneoic acid;Hexadeca-2t,4t-diensaeure;

Chemical Property of 2,4-Hexadecadienoic acid, (E,E)-

Chemical Property:

• Melting Point: 62.5-63.5 °C(Solv: acetonitrile (75-05-8); ligroine (8032-32-4))
• Boiling Point: 384.0±11.0 °C(Predicted)
• PSA: 37.30000
• Density: 0.919±0.06 g/cm3(Predicted)
• LogP: 5.10430

Purity/Quality:

(2E,4E)-2,4-Hexadecadienoicacid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: (2E,4E)-2,4-Hexadecadienoic acid is the absolute configuration of 2,4-Hexadecadienoic acid (H293530) which is used as a compound for the study of Langmuir’s monolayer behaviour in an air/water interface.

Technology Process of 2,4-Hexadecadienoic acid, (E,E)-

There total 7 articles about 2,4-Hexadecadienoic acid, (E,E)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

(2E,4E)-hexadecadienoic acid methyl ester (70017-68-4) → (2E,4E)-hexadecadienoic acid (59404-48-7)

Guidance literature:

With potassium hydroxide; In tetrahydrofuran; water; for 22h; Heating;

DOI:10.1071/CH03121

Reference yield:

(2E,4E)-hexadecadienoic acid ethyl ester (59404-47-6) → (2E,4E)-hexadecadienoic acid (59404-48-7)

Guidance literature:

With potassium hydroxide;

Reference yield:

Dodecanal (112-54-9) → (2E,4E)-hexadecadienoic acid (59404-48-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 68 percent / molecular sieves 4 Angstroem; lithium hydroxide / tetrahydrofuran / 40 h / Heating

2: 86 percent / potassium hydroxide / tetrahydrofuran; H₂O / 22 h / Heating

With potassium hydroxide; lithium hydroxide; 4 A molecular sieve; In tetrahydrofuran; water; 1: Horner-Wadsworth-Emmons coupling;

DOI:10.1071/CH03121

upstream raw materials:

(2E,4E)-hexadecadienoic acid ethyl ester

(2E,4E)-hexadecadienoic acid methyl ester

Dodecanal

1-bromotridecane

Downstream raw materials:

(3S,4S)-3-hexyl-4-[(2S)-2-hydroxytridecyl]oxetan-2-one

Orlistat

N-[(phenylmethoxy)carbonyl]-L-leucine (1S)-1-[[(2S,3S)-3-hexyl-4-oxo-2-oxetanyl]methyl]dodecyl ester

(2E,4E)-hexadecadienoic acid 2,2,2-trichloroethyl ester

Refernces

• 1、 Bodkin, Jennifer A.,Humphries, Edward J.,McLeod, Malcolm D.. "The total synthesis of (-)-tetrahydrolipstatin". . p. 795 - 803. Retrieved 2007/10/03.
• 2、 Strunz, George M.,Finlay, Heather J.. "Expedient synthesis of unsaturated amide alkaloids from Piper spp: Exploring the scope of recent methodology". . p. 419 - 432. Retrieved 2007/10/03.