(R)-Methyl 2-((R)-2-((tert-butoxycarbonyl)amino)propanamido)propanoate

Base Information

Chemical Name:(R)-Methyl 2-((R)-2-((tert-butoxycarbonyl)amino)propanamido)propanoate
CAS No.:59602-19-6
Molecular Formula:C₁₂H₂₂N₂O₅
Molecular Weight:274.317
Hs Code.:2924199090
DSSTox Substance ID:DTXSID80704271
Wikidata:Q82636640
Mol file:59602-19-6.mol

Synonyms:59602-19-6;(R)-Methyl 2-((R)-2-((tert-butoxycarbonyl)amino)propanamido)propanoate;(R)-methyl 2-((R)-2-(tert-butoxycarbonylamino)propanamido)propanoate;methyl (2R)-2-[[(2R)-2-[(2-methylpropan-2-yl)oxycarbonylamino]propanoyl]amino]propanoate;Boc-D-Ala-D-Ala-OMe;DTXSID80704271;MFCD12755709;AKOS015924293;I11681;A869167;Methyl N-(tert-butoxycarbonyl)-D-alanyl-D-alaninate;(R)-methyl 2-((R)-2-BOC-aminopropanamido)propanoate;(R)-Methyl2-((R)-2-((tert-butoxycarbonyl)amino)propanamido)propanoate;(R)-Methyl 2-((R)-2-(t-butoxycarbonylamino)propanamido)propanoate (Boc-D-Ala-D-Ala-OMe);methyl (2R)-2-({(2R)-2-[(tert-butoxycarbonyl)amino]propanoyl}amino)propanoate;methyl (2R)-2-[(2R)-2-{[(tert-butoxy)carbonyl]amino}propanamido]propanoate

Suppliers and Price of (R)-Methyl 2-((R)-2-((tert-butoxycarbonyl)amino)propanamido)propanoate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Crysdot
(R)-Methyl2-((R)-2-((tert-butoxycarbonyl)amino)propanamido)propanoate 95+%
1g
$ 798.00

Chemenu
(R)-Methyl2-((R)-2-((tert-butoxycarbonyl)amino)propanamido)propanoate 95%
1g
$ 754.00

Total 11 raw suppliers

Chemical Property of (R)-Methyl 2-((R)-2-((tert-butoxycarbonyl)amino)propanamido)propanoate

Chemical Property:

Boiling Point:415.4±25.0 °C(Predicted)
PKA:11.34±0.46(Predicted)
PSA：100.71000
Density:1.101±0.06 g/cm3(Predicted)
LogP:1.62200
XLogP3:1
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:7
Exact Mass:274.15287181
Heavy Atom Count:19
Complexity:349

Purity/Quality:

97% ^*data from raw suppliers

(R)-Methyl2-((R)-2-((tert-butoxycarbonyl)amino)propanamido)propanoate 95+% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC(C(=O)NC(C)C(=O)OC)NC(=O)OC(C)(C)C
Isomeric SMILES:C[C@H](C(=O)N[C@H](C)C(=O)OC)NC(=O)OC(C)(C)C

Technology Process of (R)-Methyl 2-((R)-2-((tert-butoxycarbonyl)amino)propanamido)propanoate

There total 22 articles about (R)-Methyl 2-((R)-2-((tert-butoxycarbonyl)amino)propanamido)propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 15761-38-3
L-N-Boc-Ala

: 2491-20-5
L-alanine methyl ester hydrochloride

: 19794-10-6,51513-86-1,59602-19-6,71257-75-5,71257-76-6
(S)-methyl 2-((S)-2-((tert-butoxycarbonyl)amino)propanamido)propanoate

Guidance literature:: L-N-Boc-Ala; With 4-methyl-morpholine; 4‐(4,6‐dimethoxy‐1,3,5‐triazin‐2‐yl)‐4‐methylmorpholinium toluene‐4‐sulfonate; In dichloromethane; at 0 ℃; for 1h;

L-alanine methyl ester hydrochloride; In dichloromethane; at 0 - 20 ℃;
DOI:10.1007/s10637-019-00838-9

Reference yield: 92.0%

: 10065-72-2
L-Alanine methyl ester

: 15761-38-3
L-N-Boc-Ala

: 19794-10-6,51513-86-1,59602-19-6,71257-75-5,71257-76-6
(S)-methyl 2-((S)-2-((tert-butoxycarbonyl)amino)propanamido)propanoate

Guidance literature:: With benzotriazol-1-ol; N-[3-(N,N-dimethylamino)-propyl]-N'-ethyl-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 0 - 20 ℃;
DOI:10.1039/d1ob02461b

Reference yield: 90.0%

: 50903-48-5
N-tert.butyloxycarbonyl-alanine pentafluorophenyl ester

: 128369-70-0
(S)-methyl 2-(((allyloxy)carbonyl)amino)propanoate

: 19794-10-6,51513-86-1,59602-19-6,71257-75-5,71257-76-6
(S)-methyl 2-((S)-2-((tert-butoxycarbonyl)amino)propanamido)propanoate

Guidance literature:: With tri-n-butyl-tin hydride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In dichloromethane; for 0.0833333h;
DOI:10.1016/0040-4039(91)80241-W