Velloziolone

Base Information

Chemical Name:Velloziolone
CAS No.:85614-79-5
Molecular Formula:C₂₀H₃₂O₂
Molecular Weight:304.473
Hs Code.:

Synonyms:

Suppliers and Price of Velloziolone

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Velloziolone

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of Velloziolone

There total 13 articles about Velloziolone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 142763-05-1,142796-53-0
(1S*,5R*)-1-<((1R*,2R*)-2-acetoxy-2,6,6-trimethylcyclohexyl)ethyl>-6-methylenebicyclo<3.2.1>octan-2-one

: 85614-79-5,142796-51-8,142796-54-1
(1S*,5R*)-1-<((1R*,2R*)-2-hydroxy-2,6,6-trimethylcyclohexyl)ethyl>-6-methylenebicyclo<3.2.1>octan-2-one

Guidance literature:: With potassium hydroxide; for 2h; Heating;
DOI:10.1021/jo00044a024

Reference yield:

: Acetic acid (1R,2R)-2-[2-((1S,5R)-6-iodomethyl-2-oxo-bicyclo[3.2.1]oct-1-yl)-ethyl]-1,3,3-trimethyl-cyclohexyl ester

: 85614-79-5,142796-51-8,142796-54-1
(1S*,5R*)-1-<((1R*,2R*)-2-hydroxy-2,6,6-trimethylcyclohexyl)ethyl>-6-methylenebicyclo<3.2.1>octan-2-one

Guidance literature:: With potassium hydroxide; 1,8-diazabicyclo[5.4.0]undec-7-ene; Yield given. Multistep reaction. Yields of byproduct given. Title compound not separated from byproducts; 1) benzene, 135 deg C, 3 h, 2) reflux, 2 h;
DOI:10.1021/jo00044a024

Reference yield:

: 30414-57-4
methyl 3-oxohept-6-enoate

: 85614-79-5,142796-51-8,142796-54-1
(1S*,5R*)-1-<((1R*,2R*)-2-hydroxy-2,6,6-trimethylcyclohexyl)ethyl>-6-methylenebicyclo<3.2.1>octan-2-one

Guidance literature:: Multi-step reaction with 7 steps

1: 21 h / 160 °C

2: 1) NaH, allyl alcohol / 1) DME, 15 min, 2) DME, 120 deg C, 22 h

3: 89 percent / Et₃N, NaI / pentane; acetonitrile / 0.33 h

4: Pd₂(dba)3, dppe / tetrahydrofuran / 0.75 h

5: NIS / tetrahydrofuran / 1 h

6: Bu₆Sn₂ / benzene / 0.25 h / 150 °C

7: 1) DBU, 2) 10percent methanol. KOH / 1) benzene, 135 deg C, 3 h, 2) reflux, 2 h

With potassium hydroxide; N-iodo-succinimide; tris(dibenzylideneacetone)dipalladium ⁽⁰⁾; bis(tri-n-butyltin); sodium hydride; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; allyl alcohol; 1,2-bis-(diphenylphosphino)ethane; sodium iodide; In tetrahydrofuran; acetonitrile; pentane; benzene;
DOI:10.1021/jo00044a024