8-BR-CGMP

Base Information

• Chemical Name: 8-BR-CGMP
• CAS No.: 31356-94-2
• Molecular Formula: C10H11 Br N5 O7 P
• Molecular Weight: 424.104
• Mol file: 31356-94-2.mol

Synonyms:4H-Furo[3,2-d]-1,3,2-dioxaphosphorin,guanosine deriv.; 3',5'-Cyclic 8-bromo-GMP; 8-Bromo-3',5'-cGMP;8-Bromo-3',5'-cyclic GMP; 8-Bromo-cGMP; 8-Bromo-cyclic GMP; 8-Bromoguanosine3,5'-cyclic monophosphate; 8-Bromoguanosine 3',5'-monophosphate;8-Bromoguanosine cyclic 3',5'-monophosphate; 8-Bromoguanosine cyclic3',5'-phosphate

Chemical Property of 8-BR-CGMP

Chemical Property:

• PKA: 1.01±0.60(Predicted)
• PSA: 184.62000
• Density: 2.96±0.1 g/cm3(Predicted)
• LogP: -0.18040

Purity/Quality:

98%Min ^*data from raw suppliers

8-Br-cGMP ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 8-Bromoguanosine 3'', 5'' -cyclic monophosphoric acid

Technology Process of 8-BR-CGMP

There total 5 articles about 8-BR-CGMP which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 35.6%

cyclic guanosine 3',5'-monophosphate (7665-99-8,51821-84-2,59668-85-8) → 8-bromo-cyclic guanosine 3':5'-monophosphate (31356-94-2)

Guidance literature:

cyclic guanosine 3',5'-monophosphate; With bromine; In formamide; at 0 ℃; for 0.5h;

With sodium hydroxide; In water; formamide; pH=9.0;

Reference yield:

({4-[(2S,4aR,6R,7R,7aS)-6-(2-Amino-8-bromo-6-oxo-1,6-dihydro-purin-9-yl)-7-hydroxy-2-oxo-tetrahydro-2λ5-furo[3,2-d][1,3,2]dioxaphosphinin-2-yloxymethyl]-2-oxo-2H-chromen-7-yl}-carboxymethyl-amino)-acetic acid → 7-[bis(carboxymethyl)amino]-4-(hydroxymethyl)coumarin (876275-37-5) + 8-bromo-cyclic guanosine 3':5'-monophosphate (31356-94-2)

Guidance literature:

With HEPES buffer; In water; acetonitrile; pH=7.2; Quantum yield; UV-irradiation;

DOI:10.1002/anie.200502411

Reference yield:

({4-[(2R,4aR,6R,7R,7aS)-6-(2-Amino-8-bromo-6-oxo-1,6-dihydro-purin-9-yl)-7-hydroxy-2-oxo-tetrahydro-2λ5-furo[3,2-d][1,3,2]dioxaphosphinin-2-yloxymethyl]-2-oxo-2H-chromen-7-yl}-carboxymethyl-amino)-acetic acid → 7-[bis(carboxymethyl)amino]-4-(hydroxymethyl)coumarin (876275-37-5) + 8-bromo-cyclic guanosine 3':5'-monophosphate (31356-94-2)

Guidance literature:

With HEPES buffer; In water; acetonitrile; pH=7.2; Quantum yield; UV-irradiation;

DOI:10.1002/anie.200502411

upstream raw materials:

cyclic guanosine 3',5'-monophosphate