Indolizomycin

Base Information

Chemical Name:Indolizomycin
CAS No.:94935-24-7
Molecular Formula:C₁₇H₂₃NO₂
Molecular Weight:273.375
Hs Code.:
Nikkaji Number:J122.639H
Wikidata:Q76386867
Mol file:94935-24-7.mol

Synonyms:(1S,2R,3S,7R,8R)-7,8-epoxy-8a-hydroxy-1,2-dimethylene-3-(1E,3E,5E)-(5-methyl-1,3,5-heptatrienyl)octahydroindolizine;indolizomycin

Suppliers and Price of Indolizomycin

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

American Custom Chemicals Corporation
INDOLIZOMYCIN 95.00%
5MG
$ 503.54

Total 3 raw suppliers

Chemical Property of Indolizomycin

Chemical Property:

Vapor Pressure:1.44E-08mmHg at 25°C
Boiling Point:413.5°Cat760mmHg
Flash Point:203.9°C
PSA：36.00000
Density:1.2g/cm³
LogP:2.18290
XLogP3:2.7
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:3
Exact Mass:273.172878976
Heavy Atom Count:20
Complexity:509

Purity/Quality:: INDOLIZOMYCIN 95.00% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC=C(C)C=CC=CC1C2CC2C3(N1CCC4C3O4)O
Isomeric SMILES:C/C=C(\C)/C=C/C=C/[C@H]1[C@@H]2C[C@@H]2[C@]3(N1CC[C@@H]4[C@H]3O4)O

Technology Process of Indolizomycin

There total 10 articles about Indolizomycin which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 29.0%

: 125077-31-8
(1R*,3R*,5S*,9R*(1E,3E,5E),10S*)-(+/-)-9-(5-methyl-1,3,5-heptatrienyl)-2-oxo-4-oxa-8-azatricyclo<8.1.0.0^3,5>undecane-8-carboxylic acid 2-(trimethylsilyl)ethyl ester

: 94935-24-7,125134-97-6
(+/-)-indolizomycin

Guidance literature:: With tetrabutyl ammonium fluoride;
DOI:10.1021/ja00161a059

Reference yield:

: 125077-30-7
(1R*,2S*,3R*,5S*,9R*(1E,3E,5E),10S*)-(+/-)-2-hydroxy-9-(5-methyl-1,3,5-heptatrienyl)-4-oxa-8-azatricyclo<8.1.0.0^3,5>undecane-8-carboxylic acid 2-(trimethylsilyl)ethyl ester

: 94935-24-7,125134-97-6
(+/-)-indolizomycin

Guidance literature:: Multi-step reaction with 2 steps

1: 84 percent / tetra-n-propylammonium perruthenate / CH₂Cl₂ / 0.17 h / Ambient temperature

2: 29 percent / TBAF / tetrahydrofuran / 1.5 h / 0 °C

With tetrapropylammonium perruthennate; tetrabutyl ammonium fluoride; In tetrahydrofuran; dichloromethane;
DOI:10.1021/ja00054a005

Reference yield:

: 125077-27-2
(1R*,2S*,3R*,5S*,9R*(E),10S*)-(+/-)-2-<(tert-butyldimethylsilyl)oxy>-9-(3-oxo-1-propenyl)-4-oxa-8-azatricyclo<8.1.0.0^3,5>undecane-8-carboxylic acid 2-(trimethylsilyl)ethyl ester

: 94935-24-7,125134-97-6
(+/-)-indolizomycin

Guidance literature:: Multi-step reaction with 6 steps

1: 1.) n-BuLi / 1.) THF, hexane, -78 deg C, 10 min, 2.) THF, hexane, -78 deg C, 25 min

2: tetrahydrofuran; hexane / 1.25 h / Ambient temperature

3: 89 percent / 5percent sodium amalgam / tetrahydrofuran; methanol / 8 h

4: 86 percent / 1M HIO₄ / tetrahydrofuran / 24 h / Ambient temperature

5: 84 percent / tetra-n-propylammonium perruthenate / CH₂Cl₂ / 0.17 h / Ambient temperature

6: 29 percent / TBAF / tetrahydrofuran / 1.5 h / 0 °C

With sodium amalgam; n-butyllithium; tetrapropylammonium perruthennate; tetrabutyl ammonium fluoride; periodic acid; In tetrahydrofuran; methanol; hexane; dichloromethane;
DOI:10.1021/ja00054a005