2-Methyl-N-phenylimidazole

Base Information

• Chemical Name: 2-Methyl-N-phenylimidazole
• CAS No.: 60053-07-8
• Molecular Formula: C10H10N2
• Molecular Weight: 158.203
• Mol file: 60053-07-8.mol

Synonyms:2-methyl-1-phenylimidazole;2-methyl-N-phenylimidazole;2-Methyl-1-phenyl-1H-imidazole;1-phenyl-2-methyl-1H-imidazole;1-phenyl-2-methyl-imidazole;2-Methyl-1-phenyl-1H-imidazol;

Chemical Property of 2-Methyl-N-phenylimidazole

Chemical Property:

• Boiling Point: 147 °C (20 mmHg)
• PKA: 6.88±0.10(Predicted)
• PSA: 17.82000
• Density: 1.04±0.1 g/cm3(Predicted)
• LogP: 2.18070

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-Methyl-N-phenylimidazole

There total 9 articles about 2-Methyl-N-phenylimidazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

2-methylimidazole (693-98-1) + phenylboronic acid (98-80-6) → 2-methyl-1-phenyl-1H-imidazole (60053-07-8)

Guidance literature:

With N,N,N,N,-tetramethylethylenediamine; oxygen; copper(II) nitrate; In methanol; at 20 ℃; for 24h; under 760.051 Torr;

DOI:10.1002/adsc.200800730

Reference yield: 96.0%

2-methylimidazole (693-98-1) + iodobenzene (591-50-4) → 2-methyl-1-phenyl-1H-imidazole (60053-07-8)

Guidance literature:

With potassium hydroxide; In dimethyl sulfoxide; at 120 ℃; for 48h; Inert atmosphere;

DOI:10.1021/jo1022052

Reference yield: 90.0%

bromobenzene (108-86-1,52753-63-6) + 2-methylimidazole (693-98-1) → 2-methyl-1-phenyl-1H-imidazole (60053-07-8)

Guidance literature:

With sodium t-butanolate; In toluene; at 110 ℃; for 12h;

DOI:10.1039/c5nj02227d

upstream raw materials:

2-methyl-1,3-oxazol-4-carboxylic acid

aniline

3-methyl-1-phenyl-1H-pyrazole

bromobenzene

Downstream raw materials:

1-methyl-4,5-diphenylimidazo[1,5-a]quinoline

C₂₄H₁₄⁽²⁾H₄N₂

C₂₄H₁₇⁽²⁾HN₂

4,5-diphenyl-pyrrolo[1,2-a]quinoline

Refernces

• 1、 Basak, Akash,Abouelhassan, Yasmeen,Zuo, Ran,Yousaf, Hussain,Ding, Yousong,Huigens, Robert W.. "Antimicrobial peptide-inspired NH125 analogues: Bacterial and fungal biofilm-eradicating agents and rapid killers of MRSA persisters". . p. 5503 - 5512. Retrieved 2017.
• 2、 Ding, Zhiqiang,Nie, Nan,Chen, Tian,Meng, Lingxin,Wang, Gongshu,Chen, Zhangpei,Hu, Jianshe. "L-Proline N-oxide dihydrazides as an efficient ligand for cross-coupling reactions of aryl iodides and bromides with amines and phenols". supporting information. . Retrieved 2020/12/21.
• 3、 Dindarloo Inaloo, Iman,Majnooni, Sahar,Eslahi, Hassan,Esmaeilpour, Mohsen. "N -Arylation of (hetero)arylamines using aryl sulfamates and carbamates via C-O bond activation enabled by a reusable and durable nickel(0) catalyst". . p. 13266 - 13278. Retrieved 2020/10/07.