Benzenemethanol, 2-bromo-a-(4-chlorophenyl)-

Base Information

• Chemical Name: Benzenemethanol, 2-bromo-a-(4-chlorophenyl)-
• CAS No.: 60081-00-7
• Molecular Formula: C13H10BrClO
• Molecular Weight: 297.579

Synonyms:2-bromo-α-(4-chlorophenyl)benzyl alcohol;1-(4-chlorophenyl)-1-(2-bromophenyl)methanol;2-bromophenyl(4-chlorophenyl)methanol;

Chemical Property of Benzenemethanol, 2-bromo-a-(4-chlorophenyl)-

Chemical Property:

• PSA: 20.23000
• LogP: 4.18420

Purity/Quality:

(2-BROMOPHENYL)(4-CHLOROPHENYL)METHANOL ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Benzenemethanol, 2-bromo-a-(4-chlorophenyl)-

There total 3 articles about Benzenemethanol, 2-bromo-a-(4-chlorophenyl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

bromochlorobenzene (106-39-8) + ortho-bromobenzaldehyde (6630-33-7) → (2-bromophenyl)(4-chlorophenyl)methanol (60081-00-7)

Guidance literature:

bromochlorobenzene; With n-butyllithium;

ortho-bromobenzaldehyde; In tetrahydrofuran; at 0 - 20 ℃; for 1.5h; Inert atmosphere;

DOI:10.1016/j.tetlet.2016.06.123

Reference yield: 90.0%

(4-chlorphenyl)magnesium bromide (873-77-8) + ortho-bromobenzaldehyde (6630-33-7) → (2-bromophenyl)(4-chlorophenyl)methanol (60081-00-7)

Guidance literature:

In tetrahydrofuran; 2-methyltetrahydrofuran; at -30 ℃; for 1h; Inert atmosphere;

DOI:10.1002/anie.201209983

Reference yield:

bromochlorobenzene (106-39-8) + ammonium chloride + ortho-bromobenzaldehyde (6630-33-7) → (2-bromophenyl)(4-chlorophenyl)methanol (60081-00-7)

Guidance literature:

With sodium hydroxide; sodium hydrogensulfite; In tetrahydrofuran; diethyl ether; hexane; water;

upstream raw materials:

(4-chlorphenyl)magnesium bromide

ortho-bromobenzaldehyde

bromochlorobenzene

Downstream raw materials:

1-bromo-2-[(4-chlorophenyl)(methoxy)methyl]benzene

2-[1-(4-chlorophenyl)ethenyl]benzonitrile

2-(4-chlorobenzoyl)benzonitrile

3-(4-chloro-phenyl)-1'-methyl-3H-spiro[isobenzofuran-1,4'-piperidine]

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