1-(2-Chlorophenyl)-3-(2-hydroxyphenyl)propane-1,3-dione

Base Information

• Chemical Name: 1-(2-Chlorophenyl)-3-(2-hydroxyphenyl)propane-1,3-dione
• CAS No.: 60121-60-0
• Molecular Formula: C15H11ClO3
• Molecular Weight: 274.704
• DSSTox Substance ID: DTXSID50353154
• Nikkaji Number: J1.276.006J
• Wikidata: Q82130614

Synonyms:1-(2-chlorophenyl)-3-(2-hydroxyphenyl)propane-1,3-dione;60121-60-0;1,3-Propanedione, 1-(2-chlorophenyl)-3-(2-hydroxyphenyl)-;Cambridge id 5470157;Oprea1_281498;DTXSID50353154;AKOS001578264;AB00086084-01;SR-01000394876;SR-01000394876-1

Chemical Property of 1-(2-Chlorophenyl)-3-(2-hydroxyphenyl)propane-1,3-dione

Chemical Property:

• XLogP3: 3.9
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 4
• Exact Mass: 274.0396719
• Heavy Atom Count: 19
• Complexity: 342

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C(C(=C1)C(=O)CC(=O)C2=CC=CC=C2Cl)O

Technology Process of 1-(2-Chlorophenyl)-3-(2-hydroxyphenyl)propane-1,3-dione

There total 3 articles about 1-(2-Chlorophenyl)-3-(2-hydroxyphenyl)propane-1,3-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

2-acetylphenyl 2-chlorobenzoate (84634-61-7) → 1-(2-hydroxyphenyl)-3-(2-chlorophenyl)propane-1,3-dione (60121-60-0)

Guidance literature:

With potassium tert-butylate; In N,N-dimethyl-formamide; at 0 ℃; for 1.16667h; Inert atmosphere;

DOI:10.1039/b9nj00237e

Reference yield:

o-hydroxyacetophenone (118-93-4,104809-67-8) → 1-(2-hydroxyphenyl)-3-(2-chlorophenyl)propane-1,3-dione (60121-60-0)

Guidance literature:

Multi-step reaction with 2 steps

1: pyridine / 25 °C / Cooling with ice

2: potassium tert-butylate / N,N-dimethyl-formamide / 1.17 h / 0 °C / Inert atmosphere

With pyridine; potassium tert-butylate; In N,N-dimethyl-formamide;

DOI:10.1039/b9nj00237e

Reference yield:

o-chlorobenzoyl chloride (609-65-4) → 1-(2-hydroxyphenyl)-3-(2-chlorophenyl)propane-1,3-dione (60121-60-0)

Guidance literature:

Multi-step reaction with 2 steps

1: pyridine / 25 °C / Cooling with ice

2: potassium tert-butylate / N,N-dimethyl-formamide / 1.17 h / 0 °C / Inert atmosphere

With pyridine; potassium tert-butylate; In N,N-dimethyl-formamide;

DOI:10.1039/b9nj00237e

upstream raw materials:

2-acetylphenyl 2-chlorobenzoate

o-hydroxyacetophenone

o-chlorobenzoyl chloride

Downstream raw materials:

2'-Chloroflavone

3-(2-chlorobenzoyl)-2-methyl-4H-chromen-4-one

2-bromomethyl-3-(2-chlorobenzoyl)-4H-chromen-4-one

1-(2-chlorophenyl)-9H-thieno[3,4-b]chromen-9-one

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 60121-60-0 1,3-Propanedione, 1-(2-chlorophenyl)-3-(2-hydroxyphenyl)-

Send

Send

Metric Ton KG G Pound L ML

Send

Send