Thp-peg4

Base Information

• Chemical Name: Thp-peg4
• CAS No.: 60221-37-6
• Molecular Formula: C11H22O5
• Molecular Weight: 234.293
• Hs Code.: 2942000090
• DSSTox Substance ID: DTXSID40547040
• Nikkaji Number: J761.158G
• Mol file: 60221-37-6.mol

Synonyms:THP-PEG4;60221-37-6;THP-PEG3-OH;2-(2-(2-((tetrahydro-2H-pyran-2-yl)oxy)ethoxy)ethoxy)ethan-1-ol;2-{2-[2-(oxan-2-yloxy)ethoxy]ethoxy}ethan-1-ol;2-{2-[2-(Tetrahydropyran-2-yloxy)-ethoxy]-ethoxy}-ethanol;2-[2-[2-(oxan-2-yloxy)ethoxy]ethoxy]ethanol;SCHEMBL578640;DTXSID40547040;2-{2-[2-(tetrahydro-2H-pyran-2-yloxy)ethoxy]ethoxy}ethanol;AKOS037654852;BP-22825;MS-20870;HY-130216;CS-0105792;C70193;A1-06401;2-(2-{2-[(Oxan-2-yl)oxy]ethoxy}ethoxy)ethan-1-ol;2-[2-[2-(tetrahydropyranyloxy)ethoxy]ethoxy]-ethanol;2-{2-[2-(Tetrahydro-pyran-2-yloxy)-ethoxy]-ethoxy}-ethanol

Chemical Property of Thp-peg4

Chemical Property:

• Boiling Point: 270 °C
• PKA: 14.36±0.10(Predicted)
• PSA: 57.15000
• Density: 1.09±0.1 g/cm3(Predicted)
• LogP: 0.55510
• XLogP3: 0
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 9
• Exact Mass: 234.14672380
• Heavy Atom Count: 16
• Complexity: 153

Purity/Quality:

NLT 98% ^*data from raw suppliers

2-{2-[2-(Tetrahydropyran-2-yloxy)-ethoxy]-ethoxy}-ethanol 95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1CCOC(C1)OCCOCCOCCO
• Description: THP-PEG4 is PEG linker containing a THP protecting group and a terminal hydroxyl. THP is an acid labile, alcohol protecting group. The hydroxyl group can react to further derivatize the compound. The hydrophilic PEG chain increases the water solubility of the compound in aqueous environments. The water solubility properties of the PEG linker are enhanced with longer PEG chains.

Technology Process of Thp-peg4

There total 2 articles about Thp-peg4 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

3,4-dihydro-2H-pyran (110-87-2) + 2,2'-[1,2-ethanediylbis(oxy)]bisethanol (112-27-6) → 8-(1H-tetrahydropyran-2-yloxy)-3n63-dioxaoctan-1-ol (60221-37-6)

Guidance literature:

With hydrogenchloride; In water; at 20 ℃;

DOI:10.1002/chem.201702780

Reference yield: 21.0%

→ 8-(1H-tetrahydropyran-2-yloxy)-3n63-dioxaoctan-1-ol (60221-37-6)

Guidance literature:

With toluene-4-sulfonic acid; In dichloromethane; at 0 ℃; for 4h;

Reference yield: 95.0%

(E)-2-chloro-5-(4-nitrostyryl)pyridine (938435-66-6) + 8-(1H-tetrahydropyran-2-yloxy)-3n63-dioxaoctan-1-ol (60221-37-6) → C24H30N2O7

Guidance literature:

8-(1H-tetrahydropyran-2-yloxy)-3n₆³-dioxaoctan-1-ol; With sodium hydride; In 1,4-dioxane; at 20 ℃; for 3h;

(E)-2-chloro-5-(4-nitrostyryl)pyridine; In 1,4-dioxane; at 20 ℃; for 12h;

DOI:10.1080/00397911.2015.1104356

upstream raw materials:

3,4-dihydro-2H-pyran

2,2'-[1,2-ethanediylbis(oxy)]bisethanol

Downstream raw materials:

2-(2-(2-((tetrahydro-2H-pyran-2-yl)oxy)ethoxy)ethoxy)ethyl 4-methylbenzenesulfonate

8-(cholest-5-en-3β-yloxy)-3,6-dioxaoctane-1-ol

C₃₀H₄₄O₁₂S₂

5'-{2-[2-(2-bromo-ethoxy)-ethoxy]-ethoxymethyl}-5-{2-[2-(2-{4-[tris-(4-tert-butyl-phenyl)-methyl]-phenoxy}-ethoxy)-ethoxy]-ethoxymethyl}-[2,2']bipyridinyl