(S)-2-[(Diphenylphosphino)methyl]pyrrolidine, min. 97%

Base Information

• Chemical Name: (S)-2-[(Diphenylphosphino)methyl]pyrrolidine, min. 97%
• CAS No.: 60261-46-3
• Molecular Formula: C17H20NP
• Molecular Weight: 269.326
• Hs Code.: 2933990090
• Mol file: 60261-46-3.mol

Synonyms:

Chemical Property of (S)-2-[(Diphenylphosphino)methyl]pyrrolidine, min. 97%

Chemical Property:

• Refractive Index: n20/D1.614
• Boiling Point: 387.1±15.0 °C(Predicted)
• PKA: 10.46±0.10(Predicted)
• Flash Point: >110℃
• PSA: 25.62000
• Density: 1.043 g/mL at 25 °C
• LogP: 3.20010
• Sensitive.: air sensitive

Purity/Quality:

98.5% ^*data from raw suppliers

(S)-2-[(Diphenylphosphino)methyl]pyrrolidine, min. 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Uses: Catalytic ligand in:Ru-catalyzed regioselective lactonization of unsymmetrical 1,4-diols to give lactone lignansPreparation of vinylindanecarboxaldehyde by asymmetric intramolecular allylation of propenylbenzenepropanal

Technology Process of (S)-2-[(Diphenylphosphino)methyl]pyrrolidine, min. 97%

There total 19 articles about (S)-2-[(Diphenylphosphino)methyl]pyrrolidine, min. 97% which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

(S)-(-)-N-tert-butoxycarbonyl-2-<(diphenylphosphino)methyl>pyrrolidine (135055-75-3) → (2S)-2-[(diphenylphosphino)methyl]pyrrolidine (60261-46-3)

Guidance literature:

With trifluoroacetic acid; at 0 ℃; for 2h;

DOI:10.1248/cpb.39.616

Reference yield: 65.0%

(S)-2-((diphenylphosphino)methyl)pyrrolidine-1-sulfonic acid (1438408-68-4) → (2S)-2-[(diphenylphosphino)methyl]pyrrolidine (60261-46-3)

Guidance literature:

With hydrogenchloride; at 85 ℃; for 16h; Inert atmosphere;

DOI:10.1039/c3ob27460h

Reference yield: 65.0%

5-(S)-<3.3.0>-1-aza-2-thia-3-oxabicyclooctane-2,2-dioxide (132635-95-1) + triphenylphosphine (603-35-0) → (2S)-2-[(diphenylphosphino)methyl]pyrrolidine (60261-46-3)

Guidance literature:

5-(S)-<3.3.0>-1-aza-2-thia-3-oxabicyclooctane-2,2-dioxide; triphenylphosphine; With lithium; In tetrahydrofuran;

With hydrogenchloride; at 100 ℃; for 17h;

DOI:10.1039/c3dt33039g

upstream raw materials:

(S)-(-)-N-tert-butoxycarbonyl-2-<(diphenylphosphino)methyl>pyrrolidine

N-(tert-butoxycarbonyl)-L-prolinol

tert-butyl (2S)-2-{[(methylsulfonyl)oxy]methyl}-pyrrolidine-1-carboxylate

1-(tert-butoxycarbonyl)-L-proline

Downstream raw materials:

2-((E)-2-{(S)-2-[(Diphenylphosphanyl)-methyl]-pyrrolidin-1-yl}-1-methyl-vinyl)-phenol

(S)-1-[(E)-3-(4-tert-Butyl-phenyl)-2-methyl-propenyl]-2-[(diphenylphosphanyl)-methyl]-pyrrolidine

(S)-(+)-N-(N',N'-dimethylcarbamoyl)-2-<(diphenylphosphino)methyl>pyrrolidine

Refernces

• 1、 Marcum, Justin S.,Roberts, Courtney C.,Manan, Rajith S.,Cervarich, Tia N.,Meek, Simon J.. "Chiral Pincer Carbodicarbene Ligands for Enantioselective Rhodium-Catalyzed Hydroarylation of Terminal and Internal 1,3-Dienes with Indoles". supporting information. p. 15580 - 15583. Retrieved 2017/11/14.
• 2、 Newcombe, Sonya,Bobin, Mariusz,Shrikhande, Amruta,Gallop, Chris,Pace, Yannick,Yong, Helen,Gates, Rebecca,Chaudhuri, Shuvashri,Roe, Mark,Hoffmann, Eva,Viseux, Eddy M. E.. "Gold amides as anticancer drugs: Synthesis and activity studies". . p. 3255 - 3260. Retrieved 2013/06/05.