4-[Bis(4-fluorophenyl)methyl]piperidine

Base Information

Chemical Name:4-[Bis(4-fluorophenyl)methyl]piperidine
CAS No.:60285-00-9
Molecular Formula:C18H19F2N
Molecular Weight:287.352
Hs Code.:
DSSTox Substance ID:DTXSID80532036
Wikidata:Q82404339

Synonyms:4-[bis(4-fluorophenyl)methyl]piperidine;60285-00-9;SCHEMBL7319671;DTXSID80532036;NLQOKCKCAKNXFS-UHFFFAOYSA-N;4-[bis(4-fluorophenyl)-methyl]piperidine

Suppliers and Price of 4-[Bis(4-fluorophenyl)methyl]piperidine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 1 raw suppliers

Chemical Property of 4-[Bis(4-fluorophenyl)methyl]piperidine

Chemical Property:

PSA：12.03000
LogP:4.42510
XLogP3:4.2
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:3
Exact Mass:287.14855593
Heavy Atom Count:21
Complexity:278

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1CNCCC1C(C2=CC=C(C=C2)F)C3=CC=C(C=C3)F

Technology Process of 4-[Bis(4-fluorophenyl)methyl]piperidine

There total 7 articles about 4-[Bis(4-fluorophenyl)methyl]piperidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 36.06%

: 58113-36-3
4-(bis(4-fluorophenyl)methylene)piperidine

: 60285-00-9
4-[bis(4-fluorophenyl)-methyl]piperidine

Guidance literature:: With sodium tetrahydroborate; trifluoroacetic acid; In dichloromethane; at 0 - 20 ℃; for 1.5h;
DOI:10.1016/j.ejmech.2020.112866

Reference yield:

: 58113-23-8
4-[bis-(4-fluorophenyl)-methylene]-piperidine hydrochloride salt

: 60285-00-9
4-[bis(4-fluorophenyl)-methyl]piperidine

Guidance literature:: With hydrogen; palladium on activated charcoal; In acetic acid; under 4560 Torr;
DOI:10.1016/0223-5234(87)90056-0

Reference yield:

: 60284-99-3
bis(4-fluorophenyl)(piperidin-4-yl)methanol hydrochloride

: 60285-00-9
4-[bis(4-fluorophenyl)-methyl]piperidine

Guidance literature:: Multi-step reaction with 2 steps

1: conc. HCl / Heating

2: H₂ / 10percent Pd/C / acetic acid / 4560 Torr

With hydrogenchloride; hydrogen; palladium on activated charcoal; In acetic acid;
DOI:10.1016/0223-5234(87)90056-0