Hexanedioic acid, 2-hydroxy-2,3,4-trimethyl-5-methylene-

Base Information

Chemical Name:Hexanedioic acid, 2-hydroxy-2,3,4-trimethyl-5-methylene-
CAS No.:72755-26-1
Molecular Formula:C₁₀H₁₆O₅
Molecular Weight:216.234
Hs Code.:
DSSTox Substance ID:DTXSID80993567

Synonyms:72755-26-1;Hexanedioic acid, 2-hydroxy-2,3,4-trimethyl-5-methylene-;2-hydroxy-2,3,4-trimethyl-5-methylidenehexanedioic acid;DTXSID80993567

Suppliers and Price of Hexanedioic acid, 2-hydroxy-2,3,4-trimethyl-5-methylene-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of Hexanedioic acid, 2-hydroxy-2,3,4-trimethyl-5-methylene-

Chemical Property:

Vapor Pressure:3.47E-10mmHg at 25°C
Boiling Point:454.9°Cat760mmHg
Flash Point:243°C
Density:1.228g/cm³
XLogP3:0.9
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:5
Exact Mass:216.09977361
Heavy Atom Count:15
Complexity:296

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC(C(C)C(C)(C(=O)O)O)C(=C)C(=O)O

Technology Process of Hexanedioic acid, 2-hydroxy-2,3,4-trimethyl-5-methylene-

There total 9 articles about Hexanedioic acid, 2-hydroxy-2,3,4-trimethyl-5-methylene- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

: 76632-60-5
5-Cyan-5-hydroxy-3,4-dimethyl-1-hexen-2-carbonsaeureethylester

: 72755-26-1
(+/-)-Senecivernic acid

Guidance literature:: With hydrogenchloride; 1.) cooling, 12 h, 2.) heating, 6 h;
DOI:10.1002/ardp.19803130910

Reference yield:

: 53496-45-0,53538-95-7,114764-52-2,114789-63-8,115936-19-1,116660-75-4,565-79-7
4-hydroxy-3-methyl-pentan-2-one

: 72755-26-1
(+/-)-Senecivernic acid

Guidance literature:: Multi-step reaction with 8 steps

1: 30 percent / p-TsOH / CHCl₃ / Heating

2: 60 percent / pyridine / 2 h / 0 °C

3: 10 percent / C₂H₅ONa / ethanol / 8 h / Heating

4: 1.) KOH , 2.) conc. HCl / 1.) EtOH, room temp., 3 h

5: 26 percent / diethylamine / H₂O

6: 75 percent / 2.5percent aq. HCl / 2 h / Ambient temperature

7: 55 percent / 35percent aq. H₂SO₄ / 0.25 h / 0 - 5 °C

8: 50 percent / conc. HCl / 1.) cooling, 12 h, 2.) heating, 6 h

With pyridine; hydrogenchloride; potassium hydroxide; sulfuric acid; sodium ethanolate; toluene-4-sulfonic acid; diethylamine; In ethanol; chloroform; water;
DOI:10.1002/ardp.19803130910

Reference yield:

: 76632-53-6
4-Hydroxy-3-methyl-pentan-2-on-ethylenketal

: 72755-26-1
(+/-)-Senecivernic acid

Guidance literature:: Multi-step reaction with 7 steps

1: 60 percent / pyridine / 2 h / 0 °C

2: 10 percent / C₂H₅ONa / ethanol / 8 h / Heating

3: 1.) KOH , 2.) conc. HCl / 1.) EtOH, room temp., 3 h

4: 26 percent / diethylamine / H₂O

5: 75 percent / 2.5percent aq. HCl / 2 h / Ambient temperature

6: 55 percent / 35percent aq. H₂SO₄ / 0.25 h / 0 - 5 °C

7: 50 percent / conc. HCl / 1.) cooling, 12 h, 2.) heating, 6 h

With pyridine; hydrogenchloride; potassium hydroxide; sulfuric acid; sodium ethanolate; diethylamine; In ethanol; water;
DOI:10.1002/ardp.19803130910