3-(4-Fluorophenyl)-1,8-naphthyridin-2-amine

Base Information

• Chemical Name: 3-(4-Fluorophenyl)-1,8-naphthyridin-2-amine
• CAS No.: 60467-61-0
• Molecular Formula: C14H10FN3
• Molecular Weight: 239.252
• DSSTox Substance ID: DTXSID90490956
• Wikidata: Q82335043

Synonyms:3-(4-Fluorophenyl)-1,8-naphthyridin-2-amine;60467-61-0;DTXSID90490956;EN300-364297

Chemical Property of 3-(4-Fluorophenyl)-1,8-naphthyridin-2-amine

Chemical Property:

• XLogP3: 2.8
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 1
• Exact Mass: 239.08587549
• Heavy Atom Count: 18
• Complexity: 278

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC2=CC(=C(N=C2N=C1)N)C3=CC=C(C=C3)F

Technology Process of 3-(4-Fluorophenyl)-1,8-naphthyridin-2-amine

There total 2 articles about 3-(4-Fluorophenyl)-1,8-naphthyridin-2-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

2-Aminonicotinaldehyde (7521-41-7) + 4-fluorophenylacetonitrile (459-22-3) → 2-amino-3-(4-fluorophenyl)-1,8-naphthyridine (60467-61-0)

Guidance literature:

With potassium hydroxide; Microwave irradiation;

Reference yield:

→ 2-amino-3-(4-fluorophenyl)-1,8-naphthyridine (60467-61-0)

Guidance literature:

2-Aminonicotinaldehyd, p-Fluorbenzylcyanid/Piperidin;

DOI:10.1021/jm00211a026

Reference yield: 98.0%

phthalic anhydride (85-44-9) + 2-amino-3-(4-fluorophenyl)-1,8-naphthyridine (60467-61-0) → C22H12FN3O2 (1233246-28-0)

Guidance literature:

With N,N-dimethyl-formamide; for 0.0666667h; Microwave irradiation; neat (no solvent);

upstream raw materials:

2-Aminonicotinaldehyde

4-fluorophenylacetonitrile

Downstream raw materials:

2-hydrazino-3-(4-fluorophenyl)-1,8-naphthyridine

C₂₁H₁₅FN₄

C₂₂H₁₇FN₄

C₂₂H₁₇FN₄O

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