3-acetaMido-1,2,3,4-tetrahydrocarbazole

Base Information

• Chemical Name: 3-acetaMido-1,2,3,4-tetrahydrocarbazole
• CAS No.: 60480-69-5
• Molecular Formula: C₁₄H₁₆N₂O
• Molecular Weight: 228.294
• Mol file: 60480-69-5.mol

Synonyms:N-(2,3,4,9-Tetrahydro-1H-carbazol-3-yl)-acetamide;N-(1,2,3,4-tetrahydro-carbazol-3-yl)-acetamide;Acetamide,N-(2,3,4,9-tetrahydro-1H-carbazol-3-yl);3-acetamido-1,2,3,4-tetrahydrocarbazole;

Chemical Property of 3-acetaMido-1,2,3,4-tetrahydrocarbazole

Chemical Property:

• Melting Point: 165-167℃ (ethanol water )
• Boiling Point: 493.7±34.0 °C(Predicted)
• PKA: 16.08±0.20(Predicted)
• PSA: 48.38000
• Density: 1.21±0.1 g/cm3(Predicted)
• LogP: 3.00160
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature

Purity/Quality:

98%,99%, ^*data from raw suppliers

N-(2,3,4,9-Tetrahydro-1H-carbazol-3-yl)acetamide 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-acetaMido-1,2,3,4-tetrahydrocarbazole

There total 3 articles about 3-acetaMido-1,2,3,4-tetrahydrocarbazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

acetic anhydride (108-24-7) + 2,3,4,9-tetrahydro-1H-carbazol-3-yl-amine (61894-99-3,116650-33-0,116650-34-1,134525-54-5) → N-(2,3,4,9-tetrahydro-1H-carbazol-3-yl)acetamide (60480-69-5)

Guidance literature:

With triethylamine; In dichloromethane; at 20 ℃; for 0.25h;

DOI:10.1002/adsc.201300993

Reference yield:

N-(4-oxocyclohexyl)acetamide (27514-08-5) → N-(2,3,4,9-tetrahydro-1H-carbazol-3-yl)acetamide (60480-69-5)

Guidance literature:

Reference yield:

→ N-(2,3,4,9-tetrahydro-1H-carbazol-3-yl)acetamide (60480-69-5)

Guidance literature:

DOI:10.1021/jm00214a005

upstream raw materials:

acetic anhydride

2,3,4,9-tetrahydro-1H-carbazol-3-yl-amine

N-(4-oxocyclohexyl)acetamide

Refernces

• 1、 Busto, Eduardo,Simon, Robert C.,Grischek, Barbara,Gotor-Fernandez, Vicente,Kroutil, Wolfgang. "Cutting short the asymmetric synthesis of the ramatroban precursor by employing ω-transaminases". supporting information. p. 1937 - 1942. Retrieved 2014/07/07.
• 2、 -. "3-Amido-1,2,3,4-tetrahydrocarbazoles". . . Retrieved 2008/06/13.