1-(4-Chlorophenyl)-2-[(4-methylphenyl)amino]ethan-1-one

Base Information

• Chemical Name: 1-(4-Chlorophenyl)-2-[(4-methylphenyl)amino]ethan-1-one
• CAS No.: 60532-55-0
• Molecular Formula: C15H14ClNO
• Molecular Weight: 259.735
• DSSTox Substance ID: DTXSID40395427
• Nikkaji Number: J1.233.965H
• Wikidata: Q82195516
• Mol file: 60532-55-0.mol

Synonyms:60532-55-0;1-(4-chlorophenyl)-2-[(4-methylphenyl)amino]ethan-1-one;1-(4-chlorophenyl)-2-(4-methylanilino)ethanone;1-(4-chlorophenyl)-2-(4-toluidino)-1-ethanone;Ethanone, 1-(4-chlorophenyl)-2-[(4-methylphenyl)amino]-;Oprea1_349118;DTXSID40395427;AKOS003262128;1-(4-Chlorophenyl)-2-(p-tolylamino)ethanone;4'-Chloro-alpha-(4-methylanilino)acetophenone;8K-905

Chemical Property of 1-(4-Chlorophenyl)-2-[(4-methylphenyl)amino]ethan-1-one

Chemical Property:

• PSA: 29.10000
• LogP: 4.01620
• XLogP3: 4.3
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 4
• Exact Mass: 259.0763918
• Heavy Atom Count: 18
• Complexity: 266

Purity/Quality:

1-(4-CHLOROPHENYL)-2-(4-TOLUIDINO)-1-ETHANONE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: CC1=CC=C(C=C1)NCC(=O)C2=CC=C(C=C2)Cl

Technology Process of 1-(4-Chlorophenyl)-2-[(4-methylphenyl)amino]ethan-1-one

There total 7 articles about 1-(4-Chlorophenyl)-2-[(4-methylphenyl)amino]ethan-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

p-toluidine (106-49-0,12221-03-3) + 4-chlorobenzoylmethyl bromide (536-38-9) → 1-(4-chloro-phenyl)-2-p-toluidino-ethanone (60532-55-0)

Guidance literature:

In diethyl ether; Ambient temperature;

Reference yield:

para-chloroacetophenone (99-91-2) + p-toluidine (106-49-0,12221-03-3) → 1-(4-chloro-phenyl)-2-p-toluidino-ethanone (60532-55-0)

Guidance literature:

With hydroxy(tosyloxy)iodobenzene; Multistep reaction; 1.) acetonitrile, reflux, 2 h, 2.) acetonitrile, reflux, 2 h;

Reference yield:

1-(4-chlorophenyl)-2-(p-tolylsulfonyloxy)ethanone (25917-49-1) + p-toluidine (106-49-0,12221-03-3) → 1-(4-chloro-phenyl)-2-p-toluidino-ethanone (60532-55-0)

Guidance literature:

In methanol; acetonitrile; at 45 ℃; Rate constant; various solvent compositions;

upstream raw materials:

p-toluidine

4-chlorobenzoylmethyl bromide

1-(4-chlorophenyl)-2-(p-tolylsulfonyloxy)ethanone

p-chlorophenacyl benzenesulphonate

Downstream raw materials:

4-(4-Chloro-phenyl)-2-methyl-1-p-tolyl-1H-pyrrole-3-carboxylic acid ethyl ester

[2-(4-Chloro-phenyl)-2-oxo-ethyl]-p-tolyl-thiocarbamic acid O-phenyl ester

2-amino-4-(4-chlorophenyl)-1-(p-tolyl)pyrrole-3-carbonitrile

2-(4-chlorophenyl)-5-methyl-1H-indole

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