Synonyms:3-lithiopyridine;pyridin-3-yllithium;60573-68-4;Lithium, 3-pyridinyl-;3-pyridyllithium;3-pyridinyl lithium;DTXSID60456029;SCLNWFIWHVOZCR-UHFFFAOYSA-N
The research aimed to further explore the structure-activity relationships of the antifungal lead compound α-trichloromethyl-3-pyridinemethanol (1a) by synthesizing and evaluating its derivatives, including esters, (thio-)carbamates, and sulfonates. The study involved the optical resolution and N-oxidation of 1a, providing insights into the effects of structural variations on antifungal activity. Key chemicals used in the synthesis process included 3-Pyridyllithium, Chloral, Isocyanates, Car-Bamoylchlorides, Triethylamin, and various other reagents for the preparation of different derivatives. The conclusions drawn from the research detailed the successful synthesis and characterization of the derivatives, as well as their antifungal properties, thereby expanding the understanding of the lead structure's potential as a fungicide.
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