Chemical Property of CID 12311263
Chemical Property:
- Vapor Pressure:0mmHg at 25°C
- Melting Point:190-191oC
- Refractive Index:1.589
- Boiling Point:434.5oC at 760 mmHg
- Flash Point:216.6oC
- PSA：51.97000
- Density:1.3 g/cm3
- LogP:2.60610
- Storage Temp.:-20°C
- Solubility.:Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)
- XLogP3:1.9
- Hydrogen Bond Donor Count:0
- Hydrogen Bond Acceptor Count:4
- Rotatable Bond Count:0
- Exact Mass:260.10485899
- Heavy Atom Count:19
- Complexity:457
- Purity/Quality:
-
99%, *data from raw suppliers
Linderane *data from reagent suppliers
Safty Information:
- Pictogram(s):
- Hazard Codes:
- Safety Statements:
24/25
- MSDS Files:
-
SDS file from LookChem
Useful:
- Canonical SMILES:CC1=CCCC23C(O2)C(C4=C(C1)OC=C4C)OC3=O
- Isomeric SMILES:C/C/1=C/CC[C@@]23[C@@H](O2)[C@H](C4=C(C1)OC=C4C)OC3=O
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Description
Linderane is a sesquiterpene that has been found in L. aggregata. It inhibits the cytochrome P450 (CYP) isoform CYP2C9 (Ki = 1.26 μM) in an irreversible and NADPH-dependent manner. Linderane decreases phosphoenolpyruvate carboxykinase (Pck1) and glucose-6-phosphatase (G6pc) gene expression, cAMP concentration, and CREB phosphorylation, increases phosphodiesterase 3 (PDE3) activity, and inhibits gluconeogenesis in rat primary hepatocytes. In vivo, linderane (50 mg/kg twice per day) decreases serum and hepatic triglyceride levels, as well as random-fed and fasting blood glucose levels in ob/ob mice.
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Uses
Linderane is a sequiterpene lactone extract from Lindera strychnifolia compound used as a cytotoxic agent against hepaic stellate cells.
