4-(4-chlorophenyl)cyclohexa-3,5-diene-1,2-diol

Base Information

• Chemical Name: 4-(4-chlorophenyl)cyclohexa-3,5-diene-1,2-diol
• CAS No.: 98518-03-7
• Molecular Formula: C₁₂H₁₁ClO₂
• Molecular Weight: 222.671
• Mol file: 98518-03-7.mol

Synonyms:

Chemical Property of 4-(4-chlorophenyl)cyclohexa-3,5-diene-1,2-diol

Chemical Property:

• Vapor Pressure: 2.08E-06mmHg at 25°C
• Boiling Point: 378.6°Cat760mmHg
• Flash Point: 182.8°C
• Density: 1.381g/cm³

Purity/Quality:

97% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-(4-chlorophenyl)cyclohexa-3,5-diene-1,2-diol

There total 3 articles about 4-(4-chlorophenyl)cyclohexa-3,5-diene-1,2-diol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

C15H14ClN3O4 → C12H11ClO2 (98518-03-7)

Guidance literature:

C₁₅H₁₄ClN₃O₄; With hydrazine; at 100 ℃; for 12h; Inert atmosphere;

With copper(II) choride dihydrate; In water; at 20 ℃; for 0.0833333h; pH=7;

DOI:10.1002/anie.201709712

Reference yield:

C15H12BBrClN3O4 → C12H11ClO2 (98518-03-7)

Guidance literature:

Multi-step reaction with 2 steps

1.1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; triethylamine / tetrahydrofuran; water / 4 h / 70 °C / Inert atmosphere; Sealed tube; Schlenk technique

2.1: hydrazine / 12 h / 100 °C / Inert atmosphere

2.2: 0.08 h / 20 °C / pH 7

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; triethylamine; hydrazine; In tetrahydrofuran; water;

DOI:10.1002/anie.201709712

Reference yield:

bromobenzene (108-86-1,52753-63-6) → C12H11ClO2 (98518-03-7)

Guidance literature:

Multi-step reaction with 3 steps

1.1: dichloromethane / -78 °C / Irradiation; Inert atmosphere

1.2: 8 h / Inert atmosphere; Cooling

2.1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; triethylamine / tetrahydrofuran; water / 4 h / 70 °C / Inert atmosphere; Sealed tube; Schlenk technique

3.1: hydrazine / 12 h / 100 °C / Inert atmosphere

3.2: 0.08 h / 20 °C / pH 7

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; triethylamine; hydrazine; In tetrahydrofuran; dichloromethane; water;

DOI:10.1002/anie.201709712

upstream raw materials:

bromobenzene