N-(4-Fluorophenyl)succinimide

Base Information

• Chemical Name: N-(4-Fluorophenyl)succinimide
• CAS No.: 60693-37-0
• Molecular Formula: C10H8FNO2
• Molecular Weight: 193.177
• DSSTox Substance ID: DTXSID70350009
• Nikkaji Number: J1.607.829H
• Wikidata: Q82125685
• Mol file: 60693-37-0.mol

Synonyms:N-(4-Fluorophenyl)succinimide;60693-37-0;1-(4-fluorophenyl)pyrrolidine-2,5-dione;1-(4-fluorophenyl)dihydro-1h-pyrrole-2,5-dione;1-(4-fluorophenyl)-2,5-pyrrolidinedione;1-(4-fluorophenyl)azolidine-2,5-dione;DTXSID70350009;MFCD00169601;AKOS003183501;JS-0560;SDCCGMLS-0065772.P001;1-{p-fluoro-phenyl)pyrrolidine-2,5-dione;CS-0331641;AA-768/32249049

Chemical Property of N-(4-Fluorophenyl)succinimide

Chemical Property:

• PSA: 37.38000
• LogP: 1.54410
• XLogP3: 0.3
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 1
• Exact Mass: 193.05390666
• Heavy Atom Count: 14
• Complexity: 243

Purity/Quality:

99% ^*data from raw suppliers

N-(4-Fluorophenyl)succinimide 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1CC(=O)N(C1=O)C2=CC=C(C=C2)F

Technology Process of N-(4-Fluorophenyl)succinimide

There total 12 articles about N-(4-Fluorophenyl)succinimide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

N-(4-fluorophenyl)succinamic acid (199461-14-8) → 1-(4-fluorophenyl)pyrrolidine-2,5-dione (60693-37-0)

Guidance literature:

With ammonium peroxodisulfate; In 1,4-dioxane; dimethyl sulfoxide; at 100 ℃; for 6h;

DOI:10.3762/bjoc.11.113

Reference yield: 84.0%

N-(4-fluorophenyl)maleimide (6633-22-3) → 1-(4-fluorophenyl)pyrrolidine-2,5-dione (60693-37-0)

Guidance literature:

With dichloro(dimethylglyoxime)(dimethylglyoximato)cobalt(III); ethyl 3-([1,1'-biphenyl]-2-yl)-3-oxopropanoate; 9-(2-mesityl)-10-methylacridinium perchlorate; In acetonitrile; at 20 ℃; for 24h; Irradiation; Inert atmosphere;

DOI:10.1021/acs.orglett.0c03665

Reference yield: 52.0%

1-(4-fluorophenyl)-5-(2-methyl-2H-1,2,3-triazol-4-ylcarbonyl)pyrrolidin-2-one (757248-57-0) → 1-(4-fluorophenyl)pyrrolidine-2,5-dione (60693-37-0)

Guidance literature:

With ammonium cerium(IV) nitrate; In acetonitrile; at 20 ℃; for 7h;

upstream raw materials:

1-(4-fluorophenyl)-4-[1,2,3-triazol-4⁽⁵⁾-ylcarbonyl]pyrrolidin-2-one

1-(4-fluorophenyl)-5-(2-methyl-2H-1,2,3-triazol-4-ylcarbonyl)pyrrolidin-2-one

methyl N-(4-fluorophenyl)pyroglutamate

5-cyanoacetyl-1-(4-fluorophenyl)pyrrolidin-2-one

Downstream raw materials:

C₂₄H₂₅FN₄O₂S

C₂₀H₁₇FN₄O₂S₂

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