Technology Process of 4-Pyridinamine,N-ethyl-2-methoxy-5-nitro-(9CI)
There total 2 articles about 4-Pyridinamine,N-ethyl-2-methoxy-5-nitro-(9CI) which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: POCl3 / toluene / 80 °C
1.2: methanol / 6 h / 15 - 20 °C
2.1: tetrahydrofuran / 72 h / 60 °C
With
trichlorophosphate;
In
tetrahydrofuran; toluene;
DOI:10.1021/jm060873p
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: 91 percent / potassium t-butoxide; t-BuOOH / tetrahydrofuran; decane; liquid ammonia / 2 h / -35 °C
2.1: POCl3 / toluene / 80 °C
2.2: methanol / 6 h / 15 - 20 °C
3.1: tetrahydrofuran / 72 h / 60 °C
With
tert.-butylhydroperoxide; potassium tert-butylate; trichlorophosphate;
In
tetrahydrofuran; decane; ammonia; toluene;
DOI:10.1021/jm060873p
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: tin(II) chloride dihdyrate / ethyl acetate / 4 h / 80 °C
2.1: 1,1'-carbonyldiimidazole / dichloromethane / 0.5 h / 20 °C
2.2: 1.5 h / 20 °C
3.1: hydrogenchloride / 1,4-dioxane / 2 h / 20 °C
4.1: sodium hydroxide / ethanol; water / 5.5 h / 80 °C
5.1: triethylamine / dichloromethane / 2 h / 0 °C
With
hydrogenchloride; tin(II) chloride dihdyrate; triethylamine; 1,1'-carbonyldiimidazole; sodium hydroxide;
In
1,4-dioxane; ethanol; dichloromethane; water; ethyl acetate;
DOI:10.1021/acs.jmedchem.5b01078
