4-Benzoyl-1,3-dihydro-2H-indol-2-one

Base Information

Chemical Name:4-Benzoyl-1,3-dihydro-2H-indol-2-one
CAS No.:61085-34-5
Molecular Formula:C15H11NO2
Molecular Weight:237.258
Hs Code.:
DSSTox Substance ID:DTXSID30512565
Wikidata:Q82371877

Synonyms:61085-34-5;4-Benzoyl-1,3-dihydro-2H-indol-2-one;4-Benzoylindolin-2-one;SCHEMBL9836593;DTXSID30512565;NCKMRUDWQDBPAO-UHFFFAOYSA-N

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Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 4-Benzoyl-1,3-dihydro-2H-indol-2-one

Chemical Property:

XLogP3:2.1
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:2
Exact Mass:237.078978594
Heavy Atom Count:18
Complexity:346

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1C2=C(C=CC=C2NC1=O)C(=O)C3=CC=CC=C3

Technology Process of 4-Benzoyl-1,3-dihydro-2H-indol-2-one

There total 5 articles about 4-Benzoyl-1,3-dihydro-2H-indol-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 61085-30-1
4-benzoyl-3-methylsulfanyl-1,3-dihydro-indol-2-one

: 61085-34-5
4-benzoylindolin-2-one

Guidance literature:: With nickel; In tetrahydrofuran; for 0.166667h;
DOI:10.1021/jm00377a001

Reference yield:

: 2835-78-1
3-amino benzophenone

: 61085-34-5
4-benzoylindolin-2-one

Guidance literature:: Multi-step reaction with 4 steps

1: tert-butyl hypochlorite / CH₂Cl₂ / 1 h / -70 °C

2: Et₃N / CH₂Cl₂ / -70 - 20 °C

3: 3N aq. HCl / CH₂Cl₂ / 2 h / Heating

4: 76 percent / Raney nickel / tetrahydrofuran / 0.17 h

With hydrogenchloride; tert-butylhypochlorite; nickel; triethylamine; In tetrahydrofuran; dichloromethane;
DOI:10.1021/jm00377a001

Reference yield:

: 65689-59-0
(2-Amino-6-benzoyl-phenyl)-methylsulfanyl-acetic acid ethyl ester

: 61085-34-5
4-benzoylindolin-2-one

Guidance literature:: Multi-step reaction with 2 steps

1: 3N aq. HCl / CH₂Cl₂ / 2 h / Heating

2: 76 percent / Raney nickel / tetrahydrofuran / 0.17 h

With hydrogenchloride; nickel; In tetrahydrofuran; dichloromethane;
DOI:10.1021/jm00377a001