5-(3,4-Dimethoxy-phenyl)-1H-pyrrolo[2,3-b]pyridine

Base Information

• Chemical Name: 5-(3,4-Dimethoxy-phenyl)-1H-pyrrolo[2,3-b]pyridine
• CAS No.: 611205-34-6
• Molecular Formula: C15H14N2O2
• Molecular Weight: 254.288
• DSSTox Substance ID: DTXSID20436165

Synonyms:611205-34-6;5-(3,4-DIMETHOXYPHENYL)-1H-PYRROLO[2,3-B]PYRIDINE;5-(3,4-Dimethoxy-phenyl)-1H-pyrrolo[2,3-b]pyridine;SCHEMBL858100;DTXSID20436165;HWVGSSNVHSEYLQ-UHFFFAOYSA-N;5-(3,4-Dimethoxy-phenyl)-1H-pyrrolo-[2,3-b]pyridine

Chemical Property of 5-(3,4-Dimethoxy-phenyl)-1H-pyrrolo[2,3-b]pyridine

Chemical Property:

• XLogP3: 2.9
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 3
• Exact Mass: 254.105527694
• Heavy Atom Count: 19
• Complexity: 300

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=C(C=C(C=C1)C2=CN=C3C(=C2)C=CN3)OC

Technology Process of 5-(3,4-Dimethoxy-phenyl)-1H-pyrrolo[2,3-b]pyridine

There total 1 articles about 5-(3,4-Dimethoxy-phenyl)-1H-pyrrolo[2,3-b]pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 46.25%

3,4-Dimethoxyphenylboronic acid (122775-35-3) + 5-bromo-1H-pyrrolo[2,3-b]pyridine (183208-35-7) → 5-(3,4-dimethoxyphenyl)-1H-pyrrolo[2,3-b]pyridine (611205-34-6)

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; In ethanol; toluene; at 120 ℃; for 24h; Inert atmosphere;

DOI:10.1007/s00044-020-02560-1

Reference yield:

5-(3,4-dimethoxyphenyl)-1H-pyrrolo[2,3-b]pyridine (611205-34-6) → 5-(3,4-Dimethoxy-phenyl)-3-iodo-1H-pyrrolo[2,3-b]pyridine (757982-98-2)

Guidance literature:

With iodine; In tetrahydrofuran; at -40 ℃; for 2h;

upstream raw materials:

3,4-Dimethoxyphenylboronic acid

5-bromo-1H-pyrrolo[2,3-b]pyridine

Downstream raw materials:

5-(3,4-Dimethoxy-phenyl)-3-iodo-1H-pyrrolo[2,3-b]pyridine

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