3-phenyl-1H-pyrido[2,3-d]pyrimidine-2,4-dione

Base Information

Chemical Name:3-phenyl-1H-pyrido[2,3-d]pyrimidine-2,4-dione
CAS No.:61212-01-9
Molecular Formula:C13H9N3O2
Molecular Weight:239.233
Hs Code.:
DSSTox Substance ID:DTXSID60356171
Wikidata:Q82135393

Synonyms:3-phenyl-1H-pyrido[2,3-d]pyrimidine-2,4-dione;61212-01-9;SCHEMBL1714306;DTXSID60356171;QTBJENXLZIUGNT-UHFFFAOYSA-N

Suppliers and Price of 3-phenyl-1H-pyrido[2,3-d]pyrimidine-2,4-dione

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 3-phenyl-1H-pyrido[2,3-d]pyrimidine-2,4-dione

Chemical Property:

XLogP3:1.4
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:1
Exact Mass:239.069476538
Heavy Atom Count:18
Complexity:352

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=CC=C(C=C1)N2C(=O)C3=C(NC2=O)N=CC=C3

Technology Process of 3-phenyl-1H-pyrido[2,3-d]pyrimidine-2,4-dione

There total 5 articles about 3-phenyl-1H-pyrido[2,3-d]pyrimidine-2,4-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.0%

: 32315-10-9
bis(trichloromethyl) carbonate

: 51071-50-2
2-amino-N-phenylnicotinamide

: 61212-01-9
3-phenylpyrido[2,3-d]pyrimidine-2,4(1H,3H)-dione

Guidance literature:: With triethylamine; In 1,2-dichloro-ethane; at -40 - 20 ℃; for 16.5h; Inert atmosphere; Reflux;
DOI:10.1002/chem.201905219

Reference yield: 47.0%

: 701-73-5
methyl N-phenyldithiocarbamate

: 93515-48-1
Potassium 2-aminopyridine-3-carboxylate

: 61212-01-9
3-phenylpyrido[2,3-d]pyrimidine-2,4(1H,3H)-dione

Guidance literature:: With mercury(II) oxide; In N,N-dimethyl-formamide; for 15h; Heating;
DOI:10.1055/s-1984-30900

Reference yield:

: 62-53-3
aniline

: 61212-01-9
3-phenylpyrido[2,3-d]pyrimidine-2,4(1H,3H)-dione

Guidance literature:: Multi-step reaction with 2 steps

1.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 0.5 h / 20 °C

1.2: 16 h / 20 °C

2.1: triethylamine / 1,2-dichloro-ethane / 16.5 h / -40 - 20 °C / Inert atmosphere; Reflux

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In 1,2-dichloro-ethane; N,N-dimethyl-formamide;
DOI:10.1002/chem.201905219