(R)-3-(2-methoxyphenoxy)propane-1,2-diol

Base Information Edit

Chemical Name:(R)-3-(2-methoxyphenoxy)propane-1,2-diol
CAS No.:61248-75-7
Molecular Formula:C10H14O4
Molecular Weight:198.219
Hs Code.:
DSSTox Substance ID:DTXSID70424976
Nikkaji Number:J71.888B
Wikidata:Q82237726
ChEMBL ID:CHEMBL1413388
Mol file:61248-75-7.mol

Synonyms:(R)-3-(2-methoxyphenoxy)propane-1,2-diol;61248-75-7;(2R)-3-(2-methoxyphenoxy)propane-1,2-diol;Fenesin;CAS-93-14-1;NCGC00016350-01;(r)-(-)-guaifenesin;SCHEMBL4322;MLS001306471;CHEMBL1413388;DTXSID70424976;HMS2230A10;AKOS006280146;SMR000718796;[R,(?)]-3-O-(o-Methoxyphenyl)-L-glycerol

Suppliers and Price of (R)-3-(2-methoxyphenoxy)propane-1,2-diol

Supply Marketing:Edit

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
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price

Total 2 raw suppliers

Chemical Property of (R)-3-(2-methoxyphenoxy)propane-1,2-diol Edit

Chemical Property:

PSA：58.92000
LogP:0.42720
XLogP3:1.4
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:5
Exact Mass:198.08920892
Heavy Atom Count:14
Complexity:151

Purity/Quality:: 98% ^*data from raw suppliers

Safty Information:

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MSDS Files:

Useful:

Canonical SMILES:COC1=CC=CC=C1OCC(CO)O
Isomeric SMILES:COC1=CC=CC=C1OC[C@@H](CO)O
General Description (R)-Guaifenesin, also known as (R)-3-(2-methoxyphenoxy)-1,2-propanediol, is an enantiomer of the racemic expectorant guaifenesin. It can be effectively resolved from its racemic mixture through preferential crystallization due to the conglomerate-forming properties of the compound, as demonstrated by thermal analysis and process development studies. This enantiomer serves as a key intermediate in the synthesis of single-enantiomer drugs such as levomoprolol and levotensin.

Technology Process of (R)-3-(2-methoxyphenoxy)propane-1,2-diol

There total 15 articles about (R)-3-(2-methoxyphenoxy)propane-1,2-diol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%