Thiazole, 5-(chloromethyl)-4-methyl-2-(4-methylphenyl)-

Base Information

Chemical Name:Thiazole, 5-(chloromethyl)-4-methyl-2-(4-methylphenyl)-
CAS No.:61291-97-2
Molecular Formula:C12H12ClNS
Molecular Weight:237.753
Hs Code.:
DSSTox Substance ID:DTXSID40486889
Wikidata:Q82328470

Synonyms:61291-97-2;Thiazole, 5-(chloromethyl)-4-methyl-2-(4-methylphenyl)-;SCHEMBL2241995;DTXSID40486889;AKOS000321093

Suppliers and Price of Thiazole, 5-(chloromethyl)-4-methyl-2-(4-methylphenyl)-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 2 raw suppliers

Chemical Property of Thiazole, 5-(chloromethyl)-4-methyl-2-(4-methylphenyl)-

Chemical Property:

XLogP3:3.8
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:2
Exact Mass:237.0378983
Heavy Atom Count:15
Complexity:204

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC1=CC=C(C=C1)C2=NC(=C(S2)CCl)C

Technology Process of Thiazole, 5-(chloromethyl)-4-methyl-2-(4-methylphenyl)-

There total 5 articles about Thiazole, 5-(chloromethyl)-4-methyl-2-(4-methylphenyl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 54001-09-1
ethyl 4-methyl-2-(p-tolyl)thiazole-5-carboxylate

: 61291-97-2
5-(chloromethyl)-4-methyl-2-(p-tolyl)thiazole

Guidance literature:: ethyl 4-methyl-2-(p-tolyl)thiazole-5-carboxylate; With sodium tetrahydroborate; In tetrahydrofuran; methanol; Reflux;

With thionyl chloride; In dichloromethane; N,N-dimethyl-formamide; at 40 ℃; for 4h;
DOI:10.1016/j.ejmech.2018.12.069

Reference yield: 87.0%

: 61291-92-7
(4-methyl-2-p-tolyl-thiazol-5-yl)-methanol

: 61291-97-2
5-(chloromethyl)-4-methyl-2-(p-tolyl)thiazole

Guidance literature:: With thionyl chloride; N,N-dimethyl-formamide; In dichloromethane; at 40 ℃; for 4h;
DOI:10.1016/j.ejmech.2016.02.040

Reference yield:

: 2362-62-1
4-methylthiobenzamide

: 61291-97-2
5-(chloromethyl)-4-methyl-2-(p-tolyl)thiazole

Guidance literature:: Multi-step reaction with 3 steps

1: ethanol / 6 h / Reflux

2: sodium tetrahydroborate / tetrahydrofuran; methanol / 0.5 h / Reflux

3: thionyl chloride; N,N-dimethyl-formamide / dichloromethane / 4 h / 40 °C

With sodium tetrahydroborate; thionyl chloride; N,N-dimethyl-formamide; In tetrahydrofuran; methanol; ethanol; dichloromethane;
DOI:10.1016/j.ejmech.2016.02.040