6-Methyl-2-(pyridin-4-yl)pyrimidin-4-amine

Base Information

• Chemical Name: 6-Methyl-2-(pyridin-4-yl)pyrimidin-4-amine
• CAS No.: 61310-35-8
• Molecular Formula: C₁₀H₁₀N₄
• Molecular Weight: 186.216
• ChEMBL ID: CHEMBL441108
• DSSTox Substance ID: DTXSID60509302
• Nikkaji Number: J1.663.258I
• Wikidata: Q82366761
• Mol file: 61310-35-8.mol

Synonyms:61310-35-8;6-Methyl-2-(pyridin-4-yl)pyrimidin-4-amine;CHEMBL441108;SCHEMBL10942195;DTXSID60509302;AKOS011473214

Chemical Property of 6-Methyl-2-(pyridin-4-yl)pyrimidin-4-amine

Chemical Property:

• Melting Point: 192-194 °C(Solv: isopropanol (67-63-0))
• Boiling Point: 288.4±32.0 °C(Predicted)
• PSA: 65.42000
• Density: 1.217±0.06 g/cm3(Predicted)
• LogP: 1.35930
• XLogP3: 0.6
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 1
• Exact Mass: 186.090546336
• Heavy Atom Count: 14
• Complexity: 179

Purity/Quality:

99% ^*data from raw suppliers

6-methyl-2-(pyridin-4-yl)pyrimidin-4-amine 95%-98% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=CC(=NC(=N1)C2=CC=NC=C2)N

Technology Process of 6-Methyl-2-(pyridin-4-yl)pyrimidin-4-amine

There total 6 articles about 6-Methyl-2-(pyridin-4-yl)pyrimidin-4-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

pyridine-4-carbonitrile (100-48-1) + acetonitrile (75-05-8,26809-02-9) → 4-amino-6-methyl-2-(4-pyridyl)pyrimidine (61310-35-8)

Guidance literature:

With lithium diisopropyl amide; In tetrahydrofuran; for 5h; Heating;

DOI:10.3987/com-01-9303

Reference yield:

4-hydrazino-6-methyl-2-(4-pyridinyl)pyrimidine (61310-34-7) → 4-amino-6-methyl-2-(4-pyridyl)pyrimidine (61310-35-8)

Guidance literature:

With hydrogen; nickel; In ethanol; at 60 - 65 ℃;

DOI:10.1021/jm00349a014

Reference yield:

4-amidinopyridine hydrochloride (6345-27-3,42518-06-9,61875-64-7) → 4-amino-6-methyl-2-(4-pyridyl)pyrimidine (61310-35-8)

Guidance literature:

Multi-step reaction with 4 steps

1: 28.2 g / CH₃ONa / methanol / 24 h / Heating

2: 100 percent / PhPOCl₂ / 6 h / 150 - 170 °C

3: 31.2 g / NH₂NH₂*H₂O / ethanol / 2 h / Heating

4: 22.6 g / H₂ / Raney Ni / ethanol / 60 - 65 °C

With P,P-dichlorophenylphosphine oxide; hydrogen; sodium methylate; hydrazine hydrate; nickel; In methanol; ethanol;

DOI:10.1021/jm00349a014

upstream raw materials:

4-hydrazino-6-methyl-2-(4-pyridinyl)pyrimidine

pyridine-4-carbonitrile

acetonitrile

4-amidinopyridine hydrochloride