2-{[2-(4-Chlorophenyl)-1,3-thiazol-4-yl]methoxy}-2-methylpropanoic acid

Base Information

Chemical Name:2-{[2-(4-Chlorophenyl)-1,3-thiazol-4-yl]methoxy}-2-methylpropanoic acid
CAS No.:61329-09-7
Molecular Formula:C₁₄H₁₄ClNO₃S
Molecular Weight:311.789
Hs Code.:
ChEMBL ID:CHEMBL350925
DSSTox Substance ID:DTXSID70564205
Nikkaji Number:J374.346B
Wikidata:Q82448821

Synonyms:61329-09-7;CHEMBL350925;DTXSID70564205;2-{[2-(4-Chlorophenyl)-1,3-thiazol-4-yl]methoxy}-2-methylpropanoic acid

Suppliers and Price of 2-{[2-(4-Chlorophenyl)-1,3-thiazol-4-yl]methoxy}-2-methylpropanoic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 2-{[2-(4-Chlorophenyl)-1,3-thiazol-4-yl]methoxy}-2-methylpropanoic acid

Chemical Property:

XLogP3:3.1
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:5
Exact Mass:311.0382922
Heavy Atom Count:20
Complexity:345

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC(C)(C(=O)O)OCC1=CSC(=N1)C2=CC=C(C=C2)Cl

Technology Process of 2-{[2-(4-Chlorophenyl)-1,3-thiazol-4-yl]methoxy}-2-methylpropanoic acid

There total 3 articles about 2-{[2-(4-Chlorophenyl)-1,3-thiazol-4-yl]methoxy}-2-methylpropanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 2-[2-(4-Chloro-phenyl)-thiazol-4-ylmethoxy]-2-methyl-propionic acid methyl ester

: 61329-09-7
2-[2-(4-chloro-phenyl)-thiazol-4-ylmethoxy]-2-methyl-propionic acid

Guidance literature:: With sodium hydroxide; In ethanol; for 1h; Yield given; Heating;
DOI:10.1021/jm00106a044

Reference yield:

: 17969-22-1
4-chloromethyl-2-(4-chloro-phenyl)-thiazole

: 61329-09-7
2-[2-(4-chloro-phenyl)-thiazol-4-ylmethoxy]-2-methyl-propionic acid

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) NaH (60percent suspension in oil) / 1.) DMF, RT, 1 h, 2.) RT, overnight

2: aq. sodium hydroxide / ethanol / 1 h / Heating

With sodium hydroxide; sodium hydride; In ethanol;
DOI:10.1021/jm00106a044