N-(4-Methylbenzene-1-sulfonyl)-L-valyl chloride

Base Information

Chemical Name:N-(4-Methylbenzene-1-sulfonyl)-L-valyl chloride
CAS No.:61341-04-6
Molecular Formula:C12H16ClNO3S
Molecular Weight:289.783
Hs Code.:
DSSTox Substance ID:DTXSID60500490

Synonyms:61341-04-6;N-(4-Methylbenzene-1-sulfonyl)-L-valyl chloride;DTXSID60500490

Suppliers and Price of N-(4-Methylbenzene-1-sulfonyl)-L-valyl chloride

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Chemical Property of N-(4-Methylbenzene-1-sulfonyl)-L-valyl chloride

Chemical Property:

XLogP3:3.2
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:5
Exact Mass:289.0539422
Heavy Atom Count:18
Complexity:381

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC1=CC=C(C=C1)S(=O)(=O)NC(C(C)C)C(=O)Cl
Isomeric SMILES:CC1=CC=C(C=C1)S(=O)(=O)N[C@@H](C(C)C)C(=O)Cl

Technology Process of N-(4-Methylbenzene-1-sulfonyl)-L-valyl chloride

There total 6 articles about N-(4-Methylbenzene-1-sulfonyl)-L-valyl chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 17360-25-7,32013-47-1,68005-71-0
N-(p-toluenesulfonyl)-L-valine

: 61341-04-6
(S)-(+)-N-tosylvaline chloride

Guidance literature:: With phosphorus pentachloride; In diethyl ether;
DOI:10.1016/S0040-4020(01)96073-9

Reference yield:

: 72-18-4,25609-85-2,7004-03-7,921-10-8
L-valine

: 61341-04-6
(S)-(+)-N-tosylvaline chloride

Guidance literature:: Multi-step reaction with 2 steps

1: 78 percent / aq. NaOH / diethyl ether / 16 h / 20 °C

2: PCl₅ / diethyl ether / 2 h / 20 °C

With sodium hydroxide; phosphorus pentachloride; In diethyl ether;
DOI:10.1039/b505324b

Reference yield:

: 98-59-9
p-toluenesulfonyl chloride

: 61341-04-6
(S)-(+)-N-tosylvaline chloride

Guidance literature:: Multi-step reaction with 2 steps

1: sodium hydroxide / tetrahydrofuran; water / 6 h

2: thionyl chloride / tetrahydrofuran / 3 h / 20 °C / Reflux

With thionyl chloride; sodium hydroxide; In tetrahydrofuran; water;
DOI:10.1002/chem.201302007