(2R)-2-Pyrrolidineacetic acid

Base Information

Chemical Name:(2R)-2-Pyrrolidineacetic acid
CAS No.:61350-65-0
Molecular Formula:C6H11NO2
Molecular Weight:129.159
Hs Code.:2933990090
UNII:2X1047YL93
DSSTox Substance ID:DTXSID30420712
Wikidata:Q27255729
ChEMBL ID:CHEMBL1163348
Mol file:61350-65-0.mol

Synonyms:61350-65-0;(2R)-2-PYRROLIDINEACETIC ACID;(R)-homoproline;(R)-PYRROLIDIN-2-YL-ACETIC ACID;(R)-2-(PYRROLIDIN-2-YL)ACETIC ACID;2-[(2R)-pyrrolidin-2-yl]acetic acid;2-Pyrrolidineacetic acid, (R)-;.beta.-Homoproline;Homoproline, (R)-;Homoproline, (-)-;(R)-2-Pyrrolidineacetic acid;CHEMBL1163348;2X1047YL93;2-PYRROLIDINEACETIC ACID, (2R)-;MFCD11505916;(-)-homoproline;2-[(2R)-pyrrolidin-2-yl]ethanoic acid;SCHEMBL288786;(r)-pyrrolidine-2-acetic acid;UNII-2X1047YL93;DTXSID30420712;CHEBI:180914;BDBM50063499;AKOS022184797;DS-3584;(R)-2-(PYRROLIDIN-2-YL)ACETICACID;CS-0035825;EN300-816454;F11179;Q27255729;7RX

Suppliers and Price of (2R)-2-Pyrrolidineacetic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
(R)-2-Pyrrolidineaceticacid
50mg
$ 110.00

J&W Pharmlab
(R)-Pyrrolidin-2-yl-aceticacid 96%
250mg
$ 109.00

J&W Pharmlab
(R)-Pyrrolidin-2-yl-aceticacid 96%
100mg
$ 98.00

J&W Pharmlab
(R)-Pyrrolidin-2-yl-aceticacid 96%
50mg
$ 88.00

J&W Pharmlab
(R)-Pyrrolidin-2-yl-aceticacid 96%
1g
$ 150.00

J&W Pharmlab
(R)-Pyrrolidin-2-yl-aceticacid 96%
500mg
$ 125.00

J&W Pharmlab
(R)-Pyrrolidin-2-yl-aceticacid 96%
5g
$ 450.00

Crysdot
(R)-2-(Pyrrolidin-2-yl)aceticacid 95+%
5g
$ 442.00

Chemenu
(R)-2-(Pyrrolidin-2-yl)aceticacid 95%
5g
$ 1397.00

Chemenu
(R)-2-(Pyrrolidin-2-yl)aceticacid 95%
1g
$ 466.00

Total 10 raw suppliers

Chemical Property of (2R)-2-Pyrrolidineacetic acid

Chemical Property:

PSA：49.33000
LogP:0.54190
Storage Temp.:2-8°C
XLogP3:-2.4
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:2
Exact Mass:129.078978594
Heavy Atom Count:9
Complexity:114

Purity/Quality:

95% ^*data from raw suppliers

(R)-2-Pyrrolidineaceticacid ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1CC(NC1)CC(=O)O
Isomeric SMILES:C1C[C@@H](NC1)CC(=O)O
Uses (R)-2-Pyrrolidineacetic Acid is used as a starting material in the synthetic preparation of GABA uptake and transport inhibitors.

Technology Process of (2R)-2-Pyrrolidineacetic acid

There total 5 articles about (2R)-2-Pyrrolidineacetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 59.0%

: 121378-50-5
N-<(S)-3-Phenyl-2-(2,2-dimethylpropionyloxy)-propionyl>-(R)-pyrrolidin-2-ylessigsaeure

: 61350-65-0
(R)-2-(pyrrolidin-2-yl)acetic acid

Guidance literature:: With sulfuric acid; at 95 ℃; for 15h;
DOI:10.1002/ardp.19893220209

Reference yield:

: 61350-64-9
(R)-2-{1-[(benzyloxy)carbonyl]pyrrolidin-2-yl}acetic acid

: 61350-65-0
(R)-2-(pyrrolidin-2-yl)acetic acid

Guidance literature:: With hydrogen; palladium on activated charcoal; In methanol; for 16h; under 760.051 Torr;
DOI:10.1021/jo800749t

Reference yield:

: 121378-48-1
<(S)-1-Benzyl-2-<(R)-2-(3,3-dimethyl-2-oxobutyl)-pyrrolodino>-2-oxoethyl>-2,2-dimethylpropionat

: 61350-65-0
(R)-2-(pyrrolidin-2-yl)acetic acid

Guidance literature:: Multi-step reaction with 2 steps

1: 77 percent / H₂O₂, (CF₃CO)2O / CH₂Cl₂ / 0.67 h / Ambient temperature

2: 59 percent / 1.5 M H₂SO₄ / 15 h / 95 °C

With sulfuric acid; dihydrogen peroxide; trifluoroacetic anhydride; In dichloromethane;
DOI:10.1002/ardp.19893220209