L-LEUCINE BETA-NAPHTHYLAMIDE HYDROCHLORIDE

Base Information

• Chemical Name: L-LEUCINE BETA-NAPHTHYLAMIDE HYDROCHLORIDE
• CAS No.: 893-36-7
• Molecular Formula: C16H20 N2 O . Cl H
• Molecular Weight: 292.809
• Hs Code.: 2924299090
• Mol file: 893-36-7.mol

Synonyms:Pentanamide,2-amino-4-methyl-N-2-naphthalenyl-, monohydrochloride, (S)-; Valeramide,2-amino-4-methyl-N-2-naphthyl-, monohydrochloride, (S)- (8CI);Leucine-2-naphthylamide hydrochloride

Chemical Property of L-LEUCINE BETA-NAPHTHYLAMIDE HYDROCHLORIDE

Chemical Property:

• Vapor Pressure: 6.76E-09mmHg at 25°C
• Melting Point: 255-260 °C (dec.)
• Refractive Index: 90 ° (C=1, H2O)
• Boiling Point: 467°C at 760 mmHg
• Flash Point: 236.2°C
• PSA: 55.12000
• LogP: 4.72700
• Storage Temp.: −20°C
• Solubility.: H2O: soluble

Purity/Quality:

98%,99%, ^*data from raw suppliers

L-Leucine b-naphthylamide hydrochloride ^*data from reagent suppliers

Safty Information:

• Safety Statements: 22-24/25

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Uses: Substrate for the assay of leucine-aminopeptidase. Substrate for leucine aminopeptidase determination in colorimetric and histochemical procedures.

Technology Process of L-LEUCINE BETA-NAPHTHYLAMIDE HYDROCHLORIDE

There total 3 articles about L-LEUCINE BETA-NAPHTHYLAMIDE HYDROCHLORIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

[(S)-3-Methyl-1-(naphthalen-2-ylcarbamoyl)-butyl]-carbamic acid tert-butyl ester (114684-54-7) → H-L-Leu-β-naphthylamide hydrochloride (893-36-7)

Guidance literature:

With hydrogenchloride; In ethyl acetate; for 2h; Ambient temperature;

DOI:10.1248/cpb.35.2698

Reference yield:

N-tert-butoxycarbonyl-L-leucine (13139-15-6,53296-34-7) → H-L-Leu-β-naphthylamide hydrochloride (893-36-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) diphenyl phosphorazidate, triethylamine / 1.) 1,2-dichloroethane, room temp., 2 h, then reflux, 15 min; 2.) 1,2-dichloroethane, reflux, 6 h

2: 78 percent / 10percent hydrogen chloride / ethyl acetate / 2 h / Ambient temperature

With hydrogenchloride; diphenyl phosphoryl azide; triethylamine; In ethyl acetate;

DOI:10.1248/cpb.35.2698

Reference yield:

naphthalene-2-carboxylate (93-09-4) → H-L-Leu-β-naphthylamide hydrochloride (893-36-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) diphenyl phosphorazidate, triethylamine / 1.) 1,2-dichloroethane, room temp., 2 h, then reflux, 15 min; 2.) 1,2-dichloroethane, reflux, 6 h

2: 78 percent / 10percent hydrogen chloride / ethyl acetate / 2 h / Ambient temperature

With hydrogenchloride; diphenyl phosphoryl azide; triethylamine; In ethyl acetate;

DOI:10.1248/cpb.35.2698

upstream raw materials:

[(S)-3-Methyl-1-(naphthalen-2-ylcarbamoyl)-butyl]-carbamic acid tert-butyl ester

N-tert-butoxycarbonyl-L-leucine

naphthalene-2-carboxylate

Downstream raw materials:

L-leucine

naphthalen-2-ylamine

Refernces