6-ACETYL-7-METHYLPYRAZOLO[1,5-A]PYRIMIDINE-3-CARBONITRILE

Base Information

• Chemical Name: 6-ACETYL-7-METHYLPYRAZOLO[1,5-A]PYRIMIDINE-3-CARBONITRILE
• CAS No.: 83702-52-7
• Molecular Formula: C₁₀H₈N₄O
• Molecular Weight: 200.2
• Hs Code.: 2933990090
• Mol file: 83702-52-7.mol

Synonyms:6-ACETYL-7-METHYLPYRAZOLO[1,5-A]PYRIMIDINE-3-CARBONITRILE

Chemical Property of 6-ACETYL-7-METHYLPYRAZOLO[1,5-A]PYRIMIDINE-3-CARBONITRILE

Chemical Property:

• Melting Point: 175-178°C
• PSA: 71.05000
• Density: 1.34g/cm³
• LogP: 1.11198

Purity/Quality:

98%min ^*data from raw suppliers

6-Acetyl-7-methylpyrazolo[1,5-a]pyrimidine-3-carbonitrile >95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 6-ACETYL-7-METHYLPYRAZOLO[1,5-A]PYRIMIDINE-3-CARBONITRILE

There total 4 articles about 6-ACETYL-7-METHYLPYRAZOLO[1,5-A]PYRIMIDINE-3-CARBONITRILE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

3-Amino-4-cyanopyrazole (16617-46-2,882231-01-8) + 3-Ethoxymethyl-pentane-2,4-dione → 6-acetyl-7-methylpyrazolo<1,5-a>pyrimidine-3-carbonitrile (83702-52-7)

Guidance literature:

In ethanol; for 1h; Heating;

Reference yield: 68.5%

6-acetyl-3-cyano-4,7-dihydro-7-methylpyrazolo<1,5-a>pyrimidine-7-carboxylic acid (83702-51-6) → 6-acetyl-7-methylpyrazolo<1,5-a>pyrimidine-3-carbonitrile (83702-52-7)

Guidance literature:

With manganese(IV) oxide; In methanol; for 7h; Ambient temperature;

Reference yield:

5a-acetyl-6a-ethoxycarbonyl-5a,6a-dihydro-6H-cyclopropapyrazolo<1,5-a>pyrimidine-3-carbonitrile (76963-66-1) → 6-acetyl-7-methylpyrazolo<1,5-a>pyrimidine-3-carbonitrile (83702-52-7)

Guidance literature:

Multi-step reaction with 3 steps

1: 51.6 percent / H₂ / 5percent Pd/C / dioxane / 4 h

2: 41.1 percent / aq.KOH / ethanol / 10 h / Heating

3: 68.5 percent / MnO₂ / methanol / 7 h / Ambient temperature

With manganese(IV) oxide; potassium hydroxide; hydrogen; palladium on activated charcoal; In 1,4-dioxane; methanol; ethanol;

upstream raw materials:

3-Amino-4-cyanopyrazole

6-acetyl-3-cyano-4,7-dihydro-7-methylpyrazolo<1,5-a>pyrimidine-7-carboxylic acid

Ethyl 6-acetyl-3-cyano-4,7-dihydro-7-methylpyrazolo<1,5-a>pyrimidine-7-carboxylate

5a-acetyl-6a-ethoxycarbonyl-5a,6a-dihydro-6H-cyclopropapyrazolo<1,5-a>pyrimidine-3-carbonitrile

Downstream raw materials:

6-acetyl-3-cyano-7-(2-dimethylaminovinyl)pyrazolo<1,5-a>pyrimidine

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