2-Bromo-2'-chloropropiophenone

Base Information

Chemical Name:2-Bromo-2'-chloropropiophenone
CAS No.:75815-22-4
Molecular Formula:C9H8 Br Cl O
Molecular Weight:247.519
Hs Code.:2914700090
European Community (EC) Number:278-320-7
DSSTox Substance ID:DTXSID00997209
Nikkaji Number:J319.141I
Mol file:75815-22-4.mol

Synonyms:2-Bromo-2'-chloropropiophenone;75815-22-4;2-BROMO-1-(2-CHLOROPHENYL)PROPAN-1-ONE;MFCD12031558;2-Bromo-2 inverted exclamation mark -chloropropiophenone;1-Propanone, 2-bromo-1-(2-chlorophenyl)-;EINECS 278-320-7;2-bromo-1-(2-chlorophenyl)-1-propanone;SCHEMBL5747509;DTXSID00997209;AC1537;AKOS027256634;DS-10182;SY031882;2-Bromo-1-(2-chlorophenyl)-propan-1-one;2-Bromo-1-(2-chloro-phenyl)-propan-1-one;CS-0186571;FT-0734241;NS00058862

Suppliers and Price of 2-Bromo-2'-chloropropiophenone

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
2-Bromo-2''-chloropropiophenone
100mg
$ 250.00

Matrix Scientific
2-Bromo-1-(2-chlorophenyl)-propan-1-one 95%+
1g
$ 580.00

Crysdot
2-Bromo-2'-chloropropiophenone 95+%
5g
$ 720.00

Crysdot
2-Bromo-2'-chloropropiophenone 95+%
1g
$ 240.00

American Custom Chemicals Corporation
2-BROMO-2'-CHLOROPROPIOPHENONE 95.00%
5MG
$ 503.58

Ambeed
2-Bromo-2'-chloropropiophenone 95+%
1g
$ 181.00

Ambeed
2-Bromo-2'-chloropropiophenone 95+%
250mg
$ 76.00

Ambeed
2-Bromo-2'-chloropropiophenone 95+%
100mg
$ 56.00

Ambeed
2-Bromo-2'-chloropropiophenone 95+%
5g
$ 576.00

Alichem
2-Bromo-2'-chloropropiophenone
250mg
$ 504.00

Total 12 raw suppliers

Chemical Property of 2-Bromo-2'-chloropropiophenone

Chemical Property:

Boiling Point:140-143 °C(Press: 15 Torr)
Flash Point:110.7oC
PSA：17.07000
Density:1.5233 g/cm3(Temp: 22 °C)
LogP:3.30610
Storage Temp.:under inert gas (nitrogen or Argon) at 2-8°C
XLogP3:3.3
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:1
Rotatable Bond Count:2
Exact Mass:245.94471
Heavy Atom Count:12
Complexity:172

Purity/Quality:

97% ^*data from raw suppliers

2-Bromo-2''-chloropropiophenone ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC(C(=O)C1=CC=CC=C1Cl)Br
Uses 2-Bromo-2''-chloropropiophenone is used as a reagent in the synthesis of 2-(tert-Butylamino)-3’,4’-dichloropropiophenone Hydrochloride (B690685); an impurity of Bupropion (B689625, HCl) which has inhibitory effects on monoamine uptake and antagonizes the effects of human α3β4*, α4β2, α4β4, and α1* nicotinic acetylcholine receptors (nAChRs).

Technology Process of 2-Bromo-2'-chloropropiophenone

There total 6 articles about 2-Bromo-2'-chloropropiophenone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 873-32-5
2-Chlorobenzonitrile

: 6323-18-8
2-chloropropiophenone

: 75815-22-4
2-bromo-2'-chloropropiophenone

Guidance literature:

Reference yield:

: 6323-18-8
2-chloropropiophenone

: 75815-22-4
2-bromo-2'-chloropropiophenone

Guidance literature:: With bromine; In tetrachloromethane;

Reference yield:

: 22869-35-8
2-chloro-α-ethylbenzyl alcohol

: 75815-22-4
2-bromo-2'-chloropropiophenone

Guidance literature:: Multi-step reaction with 2 steps

1: CrO₃; H₂SO₄ / acetone; H₂O / 10 °C

2: 48percent HBr; Br₂ / CH₂Cl₂; H₂O / 35 °C

With chromium(VI) oxide; sulfuric acid; bromine; In dichloromethane; water; acetone; 1: Jones oxidation;
DOI:10.1021/jo011042o