1-Pyrrolidinecarboxylic acid, 4-[[(1,1-dimethylethyl)diphenylsilyl]oxy]-2-(hydroxymethyl)-, 1,1-dimethylethyl ester, (2S,4R)-

Base Information

Chemical Name:1-Pyrrolidinecarboxylic acid, 4-[[(1,1-dimethylethyl)diphenylsilyl]oxy]-2-(hydroxymethyl)-, 1,1-dimethylethyl ester, (2S,4R)-
CAS No.:615582-98-4
Molecular Formula:C26H37NO4Si
Molecular Weight:455.67
Hs Code.:

Synonyms:(2S,4R)-4-(tert-Butyl-diphenyl-silanyloxy)-2-hydroxymethyl-pyrrolidine-1-carboxylic acid tert-butyl ester;

Suppliers and Price of 1-Pyrrolidinecarboxylic acid, 4-[[(1,1-dimethylethyl)diphenylsilyl]oxy]-2-(hydroxymethyl)-, 1,1-dimethylethyl ester, (2S,4R)-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

ChemScene
tert-Butyl(2S,4R)-4-((tert-butyldiphenylsilyl)oxy)-2-(hydroxymethyl)pyrrolidine-1-carboxylate
5g
$ 1420.00

Acrotein
(4R)-1-Boc-4-tert-butyldiphenylsilyloxy-L-prolinol 97%
5g
$ 907.50

Total 4 raw suppliers

Chemical Property of 1-Pyrrolidinecarboxylic acid, 4-[[(1,1-dimethylethyl)diphenylsilyl]oxy]-2-(hydroxymethyl)-, 1,1-dimethylethyl ester, (2S,4R)-

Chemical Property:

PSA：59.00000
LogP:3.87120

Purity/Quality:

NLT 98% ^*data from raw suppliers

tert-Butyl(2S,4R)-4-((tert-butyldiphenylsilyl)oxy)-2-(hydroxymethyl)pyrrolidine-1-carboxylate ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 1-Pyrrolidinecarboxylic acid, 4-[[(1,1-dimethylethyl)diphenylsilyl]oxy]-2-(hydroxymethyl)-, 1,1-dimethylethyl ester, (2S,4R)-

There total 7 articles about 1-Pyrrolidinecarboxylic acid, 4-[[(1,1-dimethylethyl)diphenylsilyl]oxy]-2-(hydroxymethyl)-, 1,1-dimethylethyl ester, (2S,4R)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 226225-42-9
(2S,4R)-N-tert-butyloxycarbonyl-4-[(tert-butyldiphenylsilyl)oxy]pyrrolidine-2-carboxylic acid methyl ester

: 615582-98-4
(2S,4R)-N-tert-butyloxycarbonyl-4-[(tert-butyldiphenylsilyl)oxy]-2-hydroxymethylpyrrolidine

Guidance literature:: With lithium borohydride; In tetrahydrofuran; at 20 ℃; for 2h;
DOI:10.1021/jm020541u

Reference yield:

: 74844-91-0
1-tert-butyl 2-methyl (2S,4R)-4-hydroxy-1,2-pyrrolidinedicarboxylate

: 615582-98-4
(2S,4R)-N-tert-butyloxycarbonyl-4-[(tert-butyldiphenylsilyl)oxy]-2-hydroxymethylpyrrolidine

Guidance literature:: Multi-step reaction with 2 steps

1: 45 percent / imidazole; DMAP / dimethylformamide / 20 °C

2: 100 percent / LiBH₄ / tetrahydrofuran / 2 h / 20 °C

With 1H-imidazole; dmap; lithium borohydride; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1021/jm020541u

Reference yield:

: 51-35-4,30724-02-8
4R-4-hydroxyproline

: 615582-98-4
(2S,4R)-N-tert-butyloxycarbonyl-4-[(tert-butyldiphenylsilyl)oxy]-2-hydroxymethylpyrrolidine

Guidance literature:: Multi-step reaction with 4 steps

1: 62 percent / aq. NaOH / 2-methyl-propan-2-ol / 20 °C

2: 95 percent / diethyl ether; methanol

3: 45 percent / imidazole; DMAP / dimethylformamide / 20 °C

4: 100 percent / LiBH₄ / tetrahydrofuran / 2 h / 20 °C

With 1H-imidazole; dmap; sodium hydroxide; lithium borohydride; In tetrahydrofuran; methanol; diethyl ether; N,N-dimethyl-formamide; tert-butyl alcohol;
DOI:10.1021/jm020541u