5-Chloro-1-oxo-2-phenyl-1lambda~5~-pyrazine

Base Information

Chemical Name:5-Chloro-1-oxo-2-phenyl-1lambda~5~-pyrazine
CAS No.:61578-12-9
Molecular Formula:C10H7ClN2O
Molecular Weight:206.631
Hs Code.:
DSSTox Substance ID:DTXSID50498231
Wikidata:Q82348154

Synonyms:61578-12-9;5-Chloro-1-oxo-2-phenyl-1lambda~5~-pyrazine;DTXSID50498231

Suppliers and Price of 5-Chloro-1-oxo-2-phenyl-1lambda~5~-pyrazine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 5-Chloro-1-oxo-2-phenyl-1lambda~5~-pyrazine

Chemical Property:

XLogP3:1.4
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:1
Exact Mass:206.0246905
Heavy Atom Count:14
Complexity:185

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=CC=C(C=C1)C2=CN=C(C=[N+]2[O-])Cl

Technology Process of 5-Chloro-1-oxo-2-phenyl-1lambda~5~-pyrazine

There total 8 articles about 5-Chloro-1-oxo-2-phenyl-1lambda~5~-pyrazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 27.0%

: 25844-73-9
2-Chloro-5-phenyl-pyrazine

: 85093-93-2
2-chloro-5-phenylpyrazine 1,4-dioxide

: 61578-12-9
2-chloro-5-phenyl-pyrazine 4-oxide

: 61578-11-8
2-chloro-5-phenylpyrazine-1-oxide

Guidance literature:: With maleic anhydride; dihydrogen peroxide; In chloroform; 1) r.t., overnight, 2) reflux, 3 h;

Reference yield:

: 25844-73-9
2-Chloro-5-phenyl-pyrazine

: 61578-12-9
2-chloro-5-phenyl-pyrazine 4-oxide

: 61578-11-8
2-chloro-5-phenylpyrazine-1-oxide

Guidance literature:: With 3-chloro-benzenecarboperoxoic acid; In 1,2-dichloro-ethane; at 70 ℃; Title compound not separated from byproducts;
DOI:10.1248/cpb.28.2734

Reference yield:

: 1074-12-0
phenylglyoxal hydrate

: 61578-12-9
2-chloro-5-phenyl-pyrazine 4-oxide

Guidance literature:: Multi-step reaction with 6 steps

1: 34 percent / KOH / ethanol / 5 h / Heating

2: 76 percent / 90percent H₂O₂, maleic anhydride / CH₂Cl₂ / 1) r.t., overnight, 2) reflux, 2 h

3: 1 h / Heating

4: 10percent KOH / methanol / 1 h / Heating

5: POCl₃, PCl₅ / 1 h / 160 °C

6: 25 percent / 90percent H₂O₂, maleic anhydride / CHCl₃ / 1) r.t., overnight, 2) reflux, 3 h

With maleic anhydride; potassium hydroxide; phosphorus pentachloride; dihydrogen peroxide; trichlorophosphate; In methanol; ethanol; dichloromethane; chloroform;